The hypoxia signaling pathway and hypoxic adaptation in fishes
W Xiao - Science China Life Sciences, 2015 - Springer
The hypoxia signaling pathway is an evolutionarily conserved cellular signaling pathway
present in animals ranging from Caenorhabditis elegans to mammals. The pathway is …
present in animals ranging from Caenorhabditis elegans to mammals. The pathway is …
Neuronal responses to physiological stress
Physiological stress can be defined as any external or internal condition that challenges the
homeostasis of a cell or an organism. It can be divided into three different aspects …
homeostasis of a cell or an organism. It can be divided into three different aspects …
A human Tau expressing zebrafish model of progressive supranuclear palsy identifies Brd4 as a regulator of microglial synaptic elimination
Progressive supranuclear palsy (PSP) is an incurable neurodegenerative disease
characterized by 4-repeat (0N/4R)-Tau protein accumulation in CNS neurons. We generated …
characterized by 4-repeat (0N/4R)-Tau protein accumulation in CNS neurons. We generated …
Radial glia regulate vascular patterning around the developing spinal cord
Vascular networks surrounding individual organs are important for their development,
maintenance, and function; however, how these networks are assembled remains poorly …
maintenance, and function; however, how these networks are assembled remains poorly …
Neural progenitor–derived Apelin controls tip cell behavior and vascular patterning
During angiogenesis, vascular tip cells guide nascent vascular sprouts to form a vascular
network. Apelin, an agonist of the G protein–coupled receptor Aplnr, is enriched in vascular …
network. Apelin, an agonist of the G protein–coupled receptor Aplnr, is enriched in vascular …
Telomere homeostasis: interplay with magnesium
Telomere biology, a key component of the hallmarks of ageing, offers insight into
dysregulation of normative ageing processes that accompany age-related diseases such as …
dysregulation of normative ageing processes that accompany age-related diseases such as …
Full-field exposure of larval zebrafish to narrow waveband LED light sources at defined power and energy for optogenetic applications
AH Burton, B Jiao, Q Bai, VS Van Laar… - Journal of Neuroscience …, 2024 - Elsevier
Background Optogenetic approaches in transparent zebrafish models have provided
numerous insights into vertebrate neurobiology. The purpose of this study was to develop …
numerous insights into vertebrate neurobiology. The purpose of this study was to develop …
Innervation modulates the functional connectivity between pancreatic endocrine cells
YHC Yang, LJB Briant, CA Raab, ST Mullapudi… - Elife, 2022 - elifesciences.org
The importance of pancreatic endocrine cell activity modulation by autonomic innervation
has been debated. To investigate this question, we established an in vivo imaging model …
has been debated. To investigate this question, we established an in vivo imaging model …
CNS-resident progenitors direct the vascularization of neighboring tissues
Organ growth requires the coordinated invasion and expansion of blood vessel networks
directed by tissue-resident cells and morphogenetic cues. A striking example of this …
directed by tissue-resident cells and morphogenetic cues. A striking example of this …
The genetic basis of chronic mountain sickness
Chronic mountain sickness (CMS) is a disease that affects many high-altitude dwellers,
particularly in the Andean Mountains in South America. The hallmark symptom of CMS is …
particularly in the Andean Mountains in South America. The hallmark symptom of CMS is …