Highlights•Sixteen leading groups review evidence for the therapeutic effects of
agmatine.•Agmatine modulatory action at multiple molecular targets is highlighted.• …

Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

Agmatine, the decarboxylation product of arginine, was largely neglected as an important
player in mammalian metabolism until the mid-1990s, when it was re-discovered as an …

Agmatine is a polyamine that is produced via decarboxylation of l-arginine by the enzyme
arginine decarboxylase. It binds to various receptors and has been accepted as a novel …

Previous research implicates altered metabolism of l-arginine, a versatile amino acid with a
number of bioactive metabolites, in the pathogenesis of schizophrenia. The present study …

The central nervous system (CNS) is the most injury-prone part of the mammalian body. Any
acute or chronic, central or peripheral neurological disorder is related to abnormal …

Agmatine is a neuromodulator that regulates multiple neurotransmitters and signaling
pathways. Several studies have focused on elucidating the mechanisms underlying the …

Agmatine, a natural polyamine produced from arginine by arginine decarboxylase, was first
discovered in 1910, but its physiological significance was disregarded for a century. The …

Agmatine is an endogenous substance, synthesized from l-arginine, and it is proposed to be
a new neurotransmitter. Preclinical studies indicated that agmatine may have an important …

Major depressive disorder is the most common psychiatric disorder with lifetime prevalence
of up to 20% worldwide. It is responsible for more years lost to disability than any other …