The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

Abstract Cadmium (Cd 2+) is a nonessential divalent metal ion that causes toxicity in
multiple organs in humans. In order for toxicity to occur Cd 2+ must first enter cells by …

Hyperpolarization‐activated cation (HCN) channels are believed to be involved in the
generation of cardiac pacemaker depolarizations as well as in the control of neuronal …

Generating new life in animals by sexual reproduction depends on adequate
communication between mature and competent male and female gametes. Ion channels are …

Abstract Cadmium (Cd 2+) is a toxic and non-essential divalent metal ion in eukaryotic cells.
Cells can only be targeted by Cd 2+ if it hijacks physiological high-affinity entry pathways …

This review is focused on the general mechanisms of metal toxicity in humans. The possible
and mainly confirmed mechanisms of their action are discussed. The metals are divided into …

The role of T-type Ca2+ channels in proliferation of tumor cells is reviewed. Intracellular
Ca2+ is important in controlling proliferation as evidenced by pulses, or oscillations, of …

Absence epilepsy, a disease predominantly of childhood, has long been known to arise from
an aberration of the interplay between two brain regions, the cortex and the thalamus …

The kidney has recently emerged as an organ with a significant role in systemic iron (Fe)
homeostasis. Substantial amounts of Fe are filtered by the kidney, which have to be …

The activity of T-type Ca2+ channels has been associated for a long time with steroid
biosynthesis in adrenal cortical cells. Because Ca2+-dependent, rate-limiting steps of …