The emerging landscape of single-molecule protein sequencing technologies

JA Alfaro, P Bohländer, M Dai, M Filius, CJ Howard… - Nature …, 2021 - nature.com
Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …

Single-molecular protein-based bioelectronics via electronic transport: fundamentals, devices and applications

T Jiang, BF Zeng, B Zhang, L Tang - Chemical Society Reviews, 2023 - pubs.rsc.org
Biomolecular electronics is a rapidly growing multidisciplinary field that combines biology,
nanoscience, and engineering to bridge the two important fields of life sciences and …

Advances in single-molecule junctions as tools for chemical and biochemical analysis

EM Dief, PJ Low, I Díez-Pérez, N Darwish - Nature Chemistry, 2023 - nature.com
The development of miniaturized electronics has led to the design and construction of
powerful experimental platforms capable of measuring electronic properties to the level of …

Molecular electronics sensors on a scalable semiconductor chip: A platform for single-molecule measurement of binding kinetics and enzyme activity

CW Fuller, PS Padayatti… - Proceedings of the …, 2022 - National Acad Sciences
For nearly 50 years, the vision of using single molecules in circuits has been seen as
providing the ultimate miniaturization of electronic chips. An advanced example of such a …

Fabrication of electron tunneling probes for measuring single-protein conductance

T Jiang, L Yi, X Liu, AP Ivanov, JB Edel, L Tang - Nature Protocols, 2023 - nature.com
Studying the electrical properties of individual proteins is a prominent research area in the
field of bioelectronics. Electron tunnelling or quantum mechanical tunnelling (QMT) probes …

Electronic transport in molecular wires of precisely controlled length built from modular proteins

B Zhang, E Ryan, X Wang, W Song, S Lindsay - ACS nano, 2022 - ACS Publications
DNA molecular wires have been studied extensively because of the ease with which
molecules of controlled length and composition can be synthesized. The same has not been …

Ultrasensitive detection of organophosphorus pesticides using single-molecule conductance measurement

X Dong, Z Tang, H Zhang, Y Hu, Z Yao… - Analytical …, 2023 - ACS Publications
Detection of organophosphorus pesticides (OPs) with high sensitivity in environmental
samples is of vital importance for environmental safety and human health. However, it …

Charge transport at the protein–electrode interface in the emerging field of BioMolecular Electronics

TQ Ha, IJ Planje, JRG White, AC Aragonès… - Current Opinion in …, 2021 - Elsevier
The emerging field of BioMolecular Electronics aims to unveil the charge transport
characteristics of biomolecules with two primary outcomes envisioned. The first is to use …

Electronic conductance resonance in non-redox-active proteins

B Zhang, W Song, J Brown, R Nemanich… - Journal of the …, 2020 - ACS Publications
Bioelectronics research has mainly focused on redox-active proteins because of their role in
biological charge transport. In these proteins, electronic conductance is a maximum when …

Measuring conductance switching in single proteins using quantum tunneling

L Tang, L Yi, T Jiang, R Ren… - Science …, 2022 - science.org
Interpreting the electrical signatures of single proteins in electronic junctions has facilitated a
better understanding of the intrinsic properties of proteins that are fundamental to chemical …