Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy

K Mortezaee, J Majidpoor - Cellular Oncology, 2022 - Springer
Macrophages are the most abundant and one of the most critical cells of tumor immunity.
They provide a bridge between innate and adaptive immunity through releasing cytokines …

Involvement of IL-4, IL-13 and their receptors in pancreatic cancer

J Shi, X Song, B Traub, M Luxenhofer… - International journal of …, 2021 - mdpi.com
Interleukin (IL)-4 and IL-13 are known as pleiotropic Th2 cytokines with a wide range of
biological properties and functions especially in immune responses. In addition, increasing …

Enhancer of zeste homolog 2 promotes renal fibrosis after acute kidney injury by inducing epithelial-mesenchymal transition and activation of M2 macrophage …

X Zhou, H Chen, Y Hu, X Ma, J Li, Y Shi, M Tao… - Cell death & …, 2023 - nature.com
Long-term follow-up data indicates that 1/4 patients with acute kidney injury (AKI) will
develop to chronic kidney disease (CKD). Our previous studies have demonstrated that …

Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment

L Duan, Y Liang, X Xu, Y Xiao, D Wang - Arthritis Research & Therapy, 2020 - Springer
Cartilage matrix remodelling homeostasis is a crucial factor in maintaining cartilage integrity.
Loss of cartilage integrity is a typical characteristic of osteoarthritis (OA). Strategies aimed at …

Estrogen and G protein-coupled estrogen receptor accelerate the progression of benign prostatic hyperplasia by inducing prostatic fibrosis

Y Yang, J Sheng, S Hu, Y Cui, J Xiao, W Yu… - Cell death & …, 2022 - nature.com
Benign prostatic hyperplasia (BPH) is the most common and progressive urological disease
in elderly men worldwide. Epidemiological studies have suggested that the speed of …

Targeting macrophages as a therapeutic option in coronavirus disease 2019

M Gracia-Hernandez, EM Sotomayor… - Frontiers in …, 2020 - frontiersin.org
Immune cells of the monocyte/macrophage lineage are characterized by their diversity,
plasticity, and variety of functions. Among them, macrophages play a central role in antiviral …

Exosomal lncRNA HOTAIR induce macrophages to M2 polarization via PI3K/p-AKT/AKT pathway and promote EMT and metastasis in laryngeal squamous cell …

J Wang, N Wang, Z Zheng, Y Che, M Suzuki, S Kano… - BMC cancer, 2022 - Springer
Exosomes are a new way of the communication between the tumor cell and macrophage in
the micro-environment. The macrophage can be induced to different phenotypes according …

Resolution of deep venous thrombosis: proposed immune paradigms

JM Nicklas, AE Gordon, PK Henke - International journal of molecular …, 2020 - mdpi.com
Venous thromboembolism (VTE) is a pathology encompassing deep vein thrombosis (DVT)
and pulmonary embolism (PE) associated with high morbidity and mortality. Because …

The role of immunosuppressive myofibroblasts in the aging process and age-related diseases

A Salminen - Journal of Molecular Medicine, 2023 - Springer
Tissue-resident fibroblasts are mesenchymal cells which control the structural integrity of the
extracellular matrix (ECM). Fibroblasts possess a remarkable plasticity to allow them to …

Mechanosensitive regulation of fibrosis

S Yang, SV Plotnikov - Cells, 2021 - mdpi.com
Cells in the human body experience and integrate a wide variety of environmental cues. A
growing interest in tissue mechanics in the past four decades has shown that the …