[HTML][HTML] Cognitive impairment induced by lead exposure during lifespan: mechanisms of lead neurotoxicity

DR Ortega, DFG Esquivel, TB Ayala, B Pineda… - Toxics, 2021 - ncbi.nlm.nih.gov
Lead (Pb) is considered a strong environmental toxin with human health repercussions. Due
to its widespread use and the number of people potentially exposed to different sources of …

Indoor particulate matter in urban households: sources, pathways, characteristics, health effects, and exposure mitigation

L Zhang, C Ou, D Magana-Arachchi… - International Journal of …, 2021 - mdpi.com
Particulate matter (PM) is a complex mixture of solid particles and liquid droplets suspended
in the air with varying size, shape, and chemical composition which intensifies significant …

Selenium nanoparticles pre-treatment reverse behavioral, oxidative damage, neuronal loss and neurochemical alterations in pentylenetetrazole-induced epileptic …

X Yuan, Z Fu, P Ji, L Guo, AO Al-Ghamdy… - International Journal …, 2020 - Taylor & Francis
Introduction Epilepsy is a chronic neurological condition characterized by behavioral,
molecular, and neurochemical alterations. Current antiepileptic drugs are associated with …

Luteolin protects against lead acetate-induced nephrotoxicity through antioxidant, anti-inflammatory, anti-apoptotic, and Nrf2/HO-1 signaling pathways

AJA Albarakati, RS Baty, AM Aljoudi, OA Habotta… - Molecular biology …, 2020 - Springer
Lead (Pb) is one of the most common heavy metal pollutants affecting living organisms. It
induces nephrotoxicity with significant alterations in renal structure and function. Luteolin …

Apple phenolic extracts ameliorate lead-induced cognitive impairment and depression-and anxiety-like behavior in mice by abating oxidative stress, inflammation and …

Y Ren, D Sun-Waterhouse, F Ouyang, X Tan, D Li… - Food & function, 2022 - pubs.rsc.org
Lead can lead to neurotoxicity and cognitive impairment. In this study, for the first time, the
protective effects and working mechanisms of apple phenolic extracts (APEs) against lead …

Increasing Nrf2 activity as a treatment approach in neuropsychiatry

G Morris, AJ Walker, K Walder, M Berk, W Marx… - Molecular …, 2021 - Springer
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …

Coenzyme Q10 activates the antioxidant machinery and inhibits the inflammatory and apoptotic cascades against lead acetate-induced renal injury in rats

WA Al-Megrin, D Soliman, RB Kassab… - Frontiers in …, 2020 - frontiersin.org
The kidney is among the metabolic organs most susceptible to injury, particularly following
exposure to xenobiotics and heavy metals. We aimed to explore the potential protective …

Cognitive Impairment Induced by lead exposure during Lifespan: mechanisms of lead neurotoxicity

D Ramírez Ortega, DF González Esquivel… - Toxics, 2021 - mdpi.com
Lead (Pb) is considered a strong environmental toxin with human health repercussions. Due
to its widespread use and the number of people potentially exposed to different sources of …

Effects of regular exercise and intermittent fasting on neurotransmitters, inflammation, oxidative stress, and brain-derived neurotrophic factor in cortex of …

T Albrahim, R Alangry, R Alotaibi, L Almandil… - Nutrients, 2023 - mdpi.com
A collection of metabolic disorders and neurodegenerative diseases linked to oxidative
stress and neuroinflammation frequently affect postmenopausal women or estrogen …

Heavy metal exposure: molecular pathways, clinical implications, and protective strategies

H Koyama, T Kamogashira, T Yamasoba - Antioxidants, 2024 - mdpi.com
Heavy metals are often found in soil and can contaminate drinking water, posing a serious
threat to human health. Molecular pathways and curation therapies for mitigating heavy …