Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

KCNQ1 is the pore-forming subunit of cardiac slow-delayed rectifier potassium (I Ks)
channels. Mutations in the kcnq1 gene are the leading cause of congenital long QT …

Abstract Phosphatidylinositol (4, 5) bisphosphate (PI (4, 5) P2) has become a major focus in
biochemistry, cell biology and physiology owing to its diverse functions at the plasma …

G protein‐coupled receptors (GPCRs) play key roles in intercellular signaling in the brain.
Their effects on cellular function have been largely studied in neurons, but their functional …

Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Examining the behavioral consequences of selective CNS neuronal activation is a powerful
tool for elucidating mammalian brain function in health and disease. Newly developed …

There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

Phosphoinositides serve as signature motifs for different cellular membranes and often are
required for the function of membrane proteins. Here, we summarize clear evidence …

KCNQ genes encode five Kv7 K+ channel subunits (Kv7. 1–Kv7. 5). Four of these (Kv7. 2–
Kv7. 5) are expressed in the nervous system. Kv7. 2 and Kv7. 3 are the principal molecular …