[HTML][HTML] The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies

T Zhong, W Zhang, H Guo, X Pan, X Chen, Q He… - … Pharmaceutica Sinica B, 2022 - Elsevier
Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …

Receptor tyrosine kinase signaling and targeting in glioblastoma multiforme

M Tilak, J Holborn, LA New, J Lalonde… - International Journal of …, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is amongst the deadliest of human cancers, with a median
survival rate of just over one year following diagnosis. Characterized by rapid proliferation …

Active constituents of saffron (Crocus sativus L.) and their prospects in treating neurodegenerative diseases

W Yang, X Qiu, Q Wu, F Chang… - Experimental and …, 2023 - spandidos-publications.com
Crocus sativus L.(saffron) is widely used as a traditional spice for flavoring, coloring and
medicinal purposes. As a traditional Chinese herb, saffron promotes blood circulation …

TRP channels in cancer: signaling mechanisms and translational approaches

M Marini, M Titiz, D Souza Monteiro de Araújo… - Biomolecules, 2023 - mdpi.com
Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …

Molecular pathways implicated in radioresistance of glioblastoma multiforme: what is the role of extracellular vesicles?

P Burko, G D'Amico, I Miltykh, F Scalia… - International Journal of …, 2023 - mdpi.com
Glioblastoma multiforme (GBM) is a primary brain tumor that is very aggressive, resistant to
treatment, and characterized by a high degree of anaplasia and proliferation. Routine …

TUNAR lncRNA encodes a microprotein that regulates neural differentiation and neurite formation by modulating calcium dynamics

E Senís, M Esgleas, S Najas… - Frontiers in cell and …, 2021 - frontiersin.org
Long noncoding RNAs (lncRNAs) are regulatory molecules which have been traditionally
considered as “non-coding”. Strikingly, recent evidence has demonstrated that many non …

Subtype specific targeting of calcium signaling in breast cancer

MR Makena, R Rao - Cell calcium, 2020 - Elsevier
An important component of breast milk, calcium also appears as radiographically prominent
microcalcifications in breast tissue that are often the earliest sign of malignancy. Ionic Ca 2+ …

Glioblastoma pharmacotherapy: A multifaceted perspective of conventional and emerging treatments

AS Sevastre, A Costachi… - Experimental and …, 2021 - spandidos-publications.com
Due to its localisation, rapid onset, high relapse rate and resistance to most currently
available treatment methods, glioblastoma multiforme (GBM) is considered to be the …

[HTML][HTML] Mitochondrial dysfunction and calcium dyshomeostasis in the pectoralis major muscle of broiler chickens with wooden breast myopathy

X Zhang, T Xing, J Li, L Zhang, F Gao - Poultry Science, 2023 - Elsevier
The incidence of wooden breast (WB) meat of commercial broiler chicken has been
increasing in recent years. Histological examination found that the occurrence of WB …

A novel TRPM7/O-GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma

S Luanpitpong, N Rodboon, P Samart… - British Journal of …, 2020 - nature.com
Background Calcium is an essential signal transduction element that has been associated
with aggressive behaviours in several cancers. Cell motility is a prerequisite for metastasis …