Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction
M Tauber, C Hoybye - The Lancet Diabetes & Endocrinology, 2021 - thelancet.com
Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss
of expression of maternally imprinted genes located in the paternal chromosomal region …
of expression of maternally imprinted genes located in the paternal chromosomal region …
Rare genetic forms of obesity: clinical approach and current treatments in 2016
Obesity results from a synergistic relationship between genes and the environment. The
phenotypic expression of genetic factors involved in obesity is variable, allowing to …
phenotypic expression of genetic factors involved in obesity is variable, allowing to …
Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism
Autism spectrum disorder (ASD) is characterized by core social deficits. Prognosis is poor, in
part, because existing medications target only associated ASD features. Emerging evidence …
part, because existing medications target only associated ASD features. Emerging evidence …
Assembling the puzzle: pathways of oxytocin signaling in the brain
V Grinevich, HS Knobloch-Bollmann, M Eliava… - Biological …, 2016 - Elsevier
Oxytocin (OT) is a neuropeptide, which can be seen to be one of the molecules of the
decade due to its profound prosocial effects in nonvertebrate and vertebrate species …
decade due to its profound prosocial effects in nonvertebrate and vertebrate species …
Oxytocin treatment, circuitry, and autism: a critical review of the literature placing oxytocin into the autism context
AJ Guastella, IB Hickie - Biological psychiatry, 2016 - Elsevier
Observed impairment in reciprocal social interaction is a diagnostic hallmark of autism
spectrum disorders. There is no effective medical treatment for these problems …
spectrum disorders. There is no effective medical treatment for these problems …
[PDF][PDF] The timing of the excitatory-to-inhibitory GABA switch is regulated by the oxytocin receptor via KCC2
M Leonzino, M Busnelli, F Antonucci, C Verderio… - Cell reports, 2016 - cell.com
Oxytocin and its receptor (Oxtr) play a crucial role in the postnatal transition of neuronal
GABA neurotransmission from excitatory to inhibitory, a developmental process known as …
GABA neurotransmission from excitatory to inhibitory, a developmental process known as …
Behavioral phenotypes of genetic mouse models of autism
TM Kazdoba, PT Leach… - Genes, Brain and …, 2016 - Wiley Online Library
More than a hundred de novo single gene mutations and copy‐number variants have been
implicated in autism, each occurring in a small subset of cases. Mutant mouse models with …
implicated in autism, each occurring in a small subset of cases. Mutant mouse models with …
The use of oxytocin to improve feeding and social skills in infants with Prader–Willi syndrome
M Tauber, K Boulanouar, G Diene… - …, 2017 - publications.aap.org
METHODS: We conducted a phase 2 escalating dose study of a short course (7 days) of
intranasal OXT administration. We enrolled 18 infants with PWS under 6 months old (6 …
intranasal OXT administration. We enrolled 18 infants with PWS under 6 months old (6 …
[HTML][HTML] The effects of oxytocin on appetite regulation, food intake and metabolism in humans
L Kerem, EA Lawson - International Journal of Molecular Sciences, 2021 - mdpi.com
The hypothalamic peptide oxytocin and its receptor are involved in a range of physiological
processes, including parturition, lactation, cell growth, wound healing, and social behavior …
processes, including parturition, lactation, cell growth, wound healing, and social behavior …
[HTML][HTML] Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism
A Bertoni, F Schaller, R Tyzio, S Gaillard, F Santini… - Molecular …, 2021 - nature.com
Oxytocin is an important regulator of the social brain. In some animal models of autism,
notably in Magel2 tm1. 1Mus-deficient mice, peripheral administration of oxytocin in infancy …
notably in Magel2 tm1. 1Mus-deficient mice, peripheral administration of oxytocin in infancy …