Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss
of expression of maternally imprinted genes located in the paternal chromosomal region …

Obesity results from a synergistic relationship between genes and the environment. The
phenotypic expression of genetic factors involved in obesity is variable, allowing to …

Autism spectrum disorder (ASD) is characterized by core social deficits. Prognosis is poor, in
part, because existing medications target only associated ASD features. Emerging evidence …

Oxytocin (OT) is a neuropeptide, which can be seen to be one of the molecules of the
decade due to its profound prosocial effects in nonvertebrate and vertebrate species …

Observed impairment in reciprocal social interaction is a diagnostic hallmark of autism
spectrum disorders. There is no effective medical treatment for these problems …

Oxytocin and its receptor (Oxtr) play a crucial role in the postnatal transition of neuronal
GABA neurotransmission from excitatory to inhibitory, a developmental process known as …

More than a hundred de novo single gene mutations and copy‐number variants have been
implicated in autism, each occurring in a small subset of cases. Mutant mouse models with …

METHODS: We conducted a phase 2 escalating dose study of a short course (7 days) of
intranasal OXT administration. We enrolled 18 infants with PWS under 6 months old (6 …

The hypothalamic peptide oxytocin and its receptor are involved in a range of physiological
processes, including parturition, lactation, cell growth, wound healing, and social behavior …

Oxytocin is an important regulator of the social brain. In some animal models of autism,
notably in Magel2 tm1. 1Mus-deficient mice, peripheral administration of oxytocin in infancy …