The cre‐loxP–mediated recombination system (the “cre‐loxP system”) is an integral
experimental tool for mammalian genetics and cell biology. Use of the system has greatly …

Tyrosine-type site-specific recombinases (T-SSRs) have opened new avenues for the
predictable modification of genomes as they enable precise genome editing in heterologous …

Mammalian organs vary widely in regenerative capacity. Poorly regenerative organs, such
as the heart are particularly vulnerable to organ failure. Once established, heart failure …

Pharmacologic activation of branched-chain amino acid (BCAA) catabolism is protective in
models of heart failure (HF). How protection occurs remains unclear, although a causative …

Specialized adult somatic cells, such as cardiomyocytes (CMs), are highly differentiated with
poor renewal capacity, an integral reason underlying organ failure in disease and aging …

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) 9
genomic editing has revolutionized the generation of mutant animals by simplifying the …

Abstract The Cre–LoxP system provides a widely used method for studying gene
requirements in the mouse as the main mammalian genetic model organism. To define the …

Mice are the most commonly used species in preclinical research on the pathophysiology of
metabolic diseases. Although they are extremely useful for identifying pathways …

During the past two decades, the field of mammalian myocardial regeneration has grown
dramatically, and with this expanded interest comes increasing claims of experimental …

It has been hypothesized that IL-1α is released from damaged cardiomyocytes following
myocardial infarction (MI) and activates cardiac fibroblasts via its receptor (IL-1R1) to drive …