Gut microbiota and short chain fatty acids: implications in glucose homeostasis

P Portincasa, L Bonfrate, M Vacca… - International journal of …, 2022 - mdpi.com
Gut microbiota encompasses a wide variety of commensal microorganisms consisting of
trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with …

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020

K Tokushige, K Ikejima, M Ono, Y Eguchi… - Journal of …, 2021 - Springer
Nonalcoholic fatty liver disease (NAFLD) has become a serious public health issue not only
in Western countries but also in Japan. Within the wide spectrum of NAFLD, nonalcoholic …

Understanding the role of the gut microbiome and microbial metabolites in non-alcoholic fatty liver disease: current evidence and perspectives

N Vallianou, GS Christodoulatos, I Karampela… - Biomolecules, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. NAFLD begins as a relatively benign hepatic steatosis which can evolve to non …

[HTML][HTML] An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease

E Lee, H Korf, A Vidal-Puig - Journal of hepatology, 2023 - Elsevier
Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

Glucagon-like peptide-1 receptor agonists for treatment of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an updated meta-analysis of randomized …

A Mantovani, G Petracca, G Beatrice, A Csermely… - Metabolites, 2021 - mdpi.com
To assess the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for
treatment of nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH), we …

GLP-1 receptor agonists in non-alcoholic fatty liver disease: current evidence and future perspectives

R Nevola, R Epifani, S Imbriani, G Tortorella… - International Journal of …, 2023 - mdpi.com
To date, non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease,
affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available …

[HTML][HTML] From NASH to diabetes and from diabetes to NASH: mechanisms and treatment options

A Gastaldelli, K Cusi - JHEP reports, 2019 - Elsevier
The worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to have
reached 25% or more in adults. NAFLD is prevalent in obese individuals, but may also affect …

Lipotoxicity and the gut-liver axis in NASH pathogenesis

F Marra, G Svegliati-Baroni - Journal of hepatology, 2018 - Elsevier
The pathogenesis of non-alcoholic fatty liver disease, particularly the mechanisms whereby
a minority of patients develop a more severe phenotype characterised by hepatocellular …

Intestinal barrier and permeability in health, obesity and NAFLD

P Portincasa, L Bonfrate, M Khalil, MD Angelis… - Biomedicines, 2021 - mdpi.com
The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation

BA McLean, CK Wong, JE Campbell… - Endocrine …, 2021 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …