Targeting hypoxia-inducible factor-1-mediated metastasis for cancer therapy
Z Ma, LZ Wang, JT Cheng, WST Lam, X Ma… - Antioxidants & redox …, 2021 - liebertpub.com
Significance: Hypoxia is emerging as a crucial regulator of the tumor microenvironment; it
governs the metastatic potential of multiple primary cancers. It is also potentially involved in …
governs the metastatic potential of multiple primary cancers. It is also potentially involved in …
[HTML][HTML] Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding motif (TAZ): a nexus between hypoxia and cancer
C Zhao, C Zeng, S Ye, X Dai, Q He, B Yang… - … Pharmaceutica Sinica B, 2020 - Elsevier
Hypoxia is a common feature of solid tumors. As transcription factors, hypoxia-inducible
factors (HIFs) are the master regulators of the hypoxic microenvironment; their target genes …
factors (HIFs) are the master regulators of the hypoxic microenvironment; their target genes …
PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma
Abstract PFKFB3 (6-phosphofructo-2-kinase) is the rate-limiting enzyme of glycolysis and is
overexpressed in several human cancers that are associated with poor prognosis. High …
overexpressed in several human cancers that are associated with poor prognosis. High …
Discovery of novel benzophenone integrated derivatives as anti-Alzheimer's agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach
The most commonly accepted hypothesis of Alzheimer's disease (AD) is the amyloid
hypothesis caused due to formation of accumulation of Aβ42 isoform, which leads to …
hypothesis caused due to formation of accumulation of Aβ42 isoform, which leads to …
ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis
S Ma, CC Lu, LY Yang, JJ Wang, BS Wang… - Journal of Experimental …, 2018 - Springer
Abstract Background ANXA2 (Annexin A2) is a pleiotropic calcium-dependent phospholipid
binding protein that is abnormally expressed in various cancers. We previously found that …
binding protein that is abnormally expressed in various cancers. We previously found that …
Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K …
L Zhang, C Chen, J Duanmu, Y Wu, J Tao… - International …, 2018 - Elsevier
The aim of this study was to evaluate the pharmacological effects of CPT on CT26 colon
cancer cells in vivo and in vitro, and to reveal the potential mechanism. CPT suppressed the …
cancer cells in vivo and in vitro, and to reveal the potential mechanism. CPT suppressed the …
[HTML][HTML] Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma
The synthesis and antiproliferative effect of a series of quinoline and thiazole containing
coumarin analogs 12a-d and 13a-f respectively, on mice leukemic cells was performed. The …
coumarin analogs 12a-d and 13a-f respectively, on mice leukemic cells was performed. The …
Quinacrine-induced autophagy in ovarian cancer triggers cathepsin-l mediated lysosomal/mitochondrial membrane permeabilization and cell death
P Thirusangu, CL Pathoulas, U Ray, Y Xiao, J Staub… - Cancers, 2021 - mdpi.com
Simple Summary Ovarian cancer (OC) is the most common cause of cancer-related deaths
among women worldwide, and its incidence has been increasing and has continued to …
among women worldwide, and its incidence has been increasing and has continued to …
Withaferin-A induced vimentin S56 phosphorylation dissociates NEDD9 signaling loop to regress progressive metastatic melanoma into lung adenocarcinoma
A Sherapura, BK Kiran, GSP Kumar… - Chemico-Biological …, 2025 - Elsevier
Metastasis is complex and insidious type of disease involves multiple signaling nexus,
which have implications in understanding disease pathogenesis. Treatment failure for …
which have implications in understanding disease pathogenesis. Treatment failure for …
Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression
FH Al-Ostoot, A Sherapura, VV, G Basappa… - Pharmacological …, 2021 - Springer
Background Hypoxic microenvironment is a common feature of solid tumors, which leads to
the promotion of cancer. The transcription factor, HIF-1α, expressed under hypoxic …
the promotion of cancer. The transcription factor, HIF-1α, expressed under hypoxic …