S‐adenosyl methionine (SAM) is a universal biological cofactor that is found in all branches
of life where it plays a critical role in the transfer of methyl groups to various biomolecules …

PWWP domain-containing proteins are often involved in chromatin-associated biological
processes, such as transcriptional regulation and DNA repair, and recent studies have …

Eukaryotic transcription is dependent on specific histone modifications. Their recognition by
chromatin readers triggers complex processes relying on the coordinated association of …

Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration
complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 …

Histone tails harbor a plethora of post-translational modifications that direct the function of
chromatin regulators, which recognize them through effector domains. Effector …

Histone-modifying enzymes are responsible for regulating transcription, recombination, DNA
repair, DNA replication, chromatid cohesion, and chromosome segregation. Fungi are …

Background Recognition of histone modifications by specialized protein domains is a key
step in the regulation of DNA-mediated processes like gene transcription. The structural …

DNA methylation is an important epigenetic modification involved in chromatin organization
and gene expression. The function of DNA methylation depends on cell context and is …

Recognition of histone-modified nucleosomes by specific reader domains underlies the
regulation of chromatin-associated processes. Whereas structural studies revealed how …

Purpose The high percentage of patients carrying germline mutations makes
pheochromocytomas/paragangliomas the most heritable of all tumors. However, there are …