The chapter reviews some of recent evidence which suggests that one neurotrophin, nerve
growth factor (NGF), is a peripherally produced mediator of some persistent pain states …

Mast cells and nerve growth factor (NGF) have both been reported to be involved in
neuroimmune interactions and tissue inflammation. In many peripheral tissues, mast cells …

In order to define the enzymes responsible for the maturation of the precursors of brain‐
derived neurotrophic factor (proBDNF) and neurotrophin‐3 (proNT3), we have analysed …

Evidence suggests that nerve growth factor (NGF) may function as a mediator of some
persistent pain states. We have used a synthetic protein, trkA-IgG, to sequester endogenous …

Nerve growth factor (NGF) is released through the constitutive secretory pathway from cells
in peripheral tissues and nerves where it can act as a target-derived survival factor. In …

The nature of neural plasticity and the factors that influence it vary throughout life. Adult
neurons undergo extensive and continual adaptation in response to demands that are quite …

Axonal transection of adult sympathetic and sensory neurons leads to a decrease in their
content of target-derived nerve growth factor (NGF) and to dramatic changes in the …

The precursor form of the nerve growth factor (proNGF), forms a heterotrimeric complex with
the receptors p75 and sortilin; this complex has been implicated in neuron cell death …

Hippocampal neurons release nerve growth factor (NGF) through the constitutive secretory
pathway, thus allowing the protein to be continuously available for promoting nerve cell …

There is growing evidence that nerve growth factor (NGF) may function as a mediator of
persistent pain states. We have identified a novel nonpeptidic molecule, ALE-0540, that …