NGF as a mediator of inflammatory pain
SB McMahon - … Transactions of the Royal Society of …, 1996 - royalsocietypublishing.org
The chapter reviews some of recent evidence which suggests that one neurotrophin, nerve
growth factor (NGF), is a peripherally produced mediator of some persistent pain states …
growth factor (NGF), is a peripherally produced mediator of some persistent pain states …
Mast cells synthesize, store, and release nerve growth factor.
A Leon, A Buriani, R Dal Toso… - Proceedings of the …, 1994 - National Acad Sciences
Mast cells and nerve growth factor (NGF) have both been reported to be involved in
neuroimmune interactions and tissue inflammation. In many peripheral tissues, mast cells …
neuroimmune interactions and tissue inflammation. In many peripheral tissues, mast cells …
Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases
NG Seidah, S Benjannet, S Pareek, M Chrétien… - FEBS …, 1996 - Wiley Online Library
In order to define the enzymes responsible for the maturation of the precursors of brain‐
derived neurotrophic factor (proBDNF) and neurotrophin‐3 (proNT3), we have analysed …
derived neurotrophic factor (proBDNF) and neurotrophin‐3 (proNT3), we have analysed …
The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule
SB McMahon, DLH Bennett, JV Priestley, DL Shelton - Nature medicine, 1995 - nature.com
Evidence suggests that nerve growth factor (NGF) may function as a mediator of some
persistent pain states. We have used a synthetic protein, trkA-IgG, to sequester endogenous …
persistent pain states. We have used a synthetic protein, trkA-IgG, to sequester endogenous …
Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons
SJ Mowla, S Pareek, HF Farhadi… - Journal of …, 1999 - Soc Neuroscience
Nerve growth factor (NGF) is released through the constitutive secretory pathway from cells
in peripheral tissues and nerves where it can act as a target-derived survival factor. In …
in peripheral tissues and nerves where it can act as a target-derived survival factor. In …
Plasticity in adult and ageing sympathetic neurons
T Cowen, I Gavazzi - Progress in neurobiology, 1998 - Elsevier
The nature of neural plasticity and the factors that influence it vary throughout life. Adult
neurons undergo extensive and continual adaptation in response to demands that are quite …
neurons undergo extensive and continual adaptation in response to demands that are quite …
Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neurons
AM Shadiack, Y Sun, RE Zigmond - Journal of Neuroscience, 2001 - Soc Neuroscience
Axonal transection of adult sympathetic and sensory neurons leads to a decrease in their
content of target-derived nerve growth factor (NGF) and to dramatic changes in the …
content of target-derived nerve growth factor (NGF) and to dramatic changes in the …
Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system
R Al‐Shawi, A Hafner, J Olson, S Chun… - European Journal of …, 2008 - Wiley Online Library
The precursor form of the nerve growth factor (proNGF), forms a heterotrimeric complex with
the receptors p75 and sortilin; this complex has been implicated in neuron cell death …
the receptors p75 and sortilin; this complex has been implicated in neuron cell death …
Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain …
HF Farhadi, SJ Mowla, K Petrecca… - Journal of …, 2000 - Soc Neuroscience
Hippocampal neurons release nerve growth factor (NGF) through the constitutive secretory
pathway, thus allowing the protein to be continuously available for promoting nerve cell …
pathway, thus allowing the protein to be continuously available for promoting nerve cell …
Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat
JB Owolabi, G Rizkalla, A Tehim, GM Ross… - … of Pharmacology and …, 1999 - ASPET
There is growing evidence that nerve growth factor (NGF) may function as a mediator of
persistent pain states. We have identified a novel nonpeptidic molecule, ALE-0540, that …
persistent pain states. We have identified a novel nonpeptidic molecule, ALE-0540, that …