The third histamine receptor was discovered in 1983 by a traditional pharmacological
approach, consisting of assessing the inhibitory effect of histamine on its own release from …

Idiopathic hypersomnia continues to evolve from the concept of “sleep drunkenness”
introduced by Bedrich Roth in Prague in 1956 and the description of idiopathic hypersomnia …

Histamine was first identified in the brain about 50 years ago, but only in the last few years
have researchers gained an understanding of how it regulates sleep/wake behavior. We …

Histamine plays pleiotropic roles as a neurotransmitter in the physiology of brain function,
this includes the maintenance of wakefulness, appetite regulation and memory retrieval …

Objective Narcolepsy is caused by loss of the hypothalamic neurons producing the
orexin/hypocretin neuropeptides. One key target of the orexin system is the histaminergic …

Background Histamine is an amine widely known as a peripheral inflammatory mediator and
as a neurotransmitter in the central nervous system. Recently, it has been suggested that …

Histamine is an amine acting as a major peripheral inflammatory mediator. In the brain,
histamine was initially viewed as a neurotransmitter, but new evidences support its …

Abstract Study Objectives: To determine the activity of cerebral histaminergic system
evaluated by CSF levels of histamine (HA) and tele-methylhistamine (t-MHA), its major …

Histamine does not only modulate the immune response and inflammation, but also acts as
a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role …

Increased sleep need following traumatic brain injury, referred to in this study as post‐
traumatic pleiosomnia, is common, but so far its clinical impact and therapeutic implications …