The identification of several germline and somatic ion channel mutations in aldosterone-
producing adenomas (APAs) and detection of cell clusters that can be responsible for …

Primary aldosteronism is characterized by at least partially autonomous production of the
adrenal steroid hormone aldosterone and is the most common cause of secondary …

Aldosterone and cortisol serve important roles in the pathogenesis of cardiovascular
diseases and metabolic disorders. Epigenetics is a mechanism to control enzyme …

Angiotensinogen (AGT) and aldosterone play key roles in the regulation of blood pressure
and are implicated in the pathogenesis of cardiovascular diseases. DNA methylation …

Aldosterone production is initiated by angiotensin II stimulation and activation of intracellular
Ca2+ signaling. In aldosterone-producing adenoma (APA) cells, the activation of …

Primary aldosteronism is the most common form of secondary hypertension with a
prevalence of 5–10% in hypertensive patients. Aldosterone-producing adenoma (APA) is a …

The endoplasmic reticulum (ER) plays a pivotal role in syntheses of proteins and steroid
hormones and regulation of intracellular Ca2+ level. We aimed to investigate ER-associated …

This review reports the main molecular alterations leading to development of benign cortisol-
and/or aldosterone-secreting adrenal tumors. Causes of adrenal Cushing syndrome can be …

Background DNA methylation is believed to be maintained in adult somatic cells. Recent
findings, however, suggest that all methylation patterns are not stable. We demonstrate that …

Primary aldosteronism (PA) is the most common form of secondary hypertension, with a
prevalence of 5–10% among patients with hypertension. PA is mainly classified into two …