Background The hormone leptin is an important regulator of metabolic homeostasis, able to
inhibit food intake and increase energy expenditure. Leptin can also independently lower …

Obesity and diabetes mellitus are great public health concerns throughout the world
because of their increasing incidence and prevalence. Leptin, the adipocyte hormone, is …

Since the discovery of leptin in 1994, we now have a better understanding of the cellular and
molecular mechanisms underlying its biological effects. In addition to its established anti …

Leptin is an adipocyte-secreted hormone that has been proposed to regulate energy
homeostasis as well as metabolic, reproductive, neuroendocrine, and immune functions. In …

Leptin plays an important role in the control of food intake, energy expenditure, metabolism,
and body weight. This hormone also has a key function in the regulation of glucose …

The fat‐derived hormone, leptin, is well known to regulate body weight. However, there is
now substantial evidence that leptin also plays a primary role in the regulation of glucose …

Obesity is characterized by hyperleptinemia and decreased response to exogenous leptin.
This has been widely attributed to the development of leptin resistance, a state of impaired …

Diabetic nephropathy, a major diabetes complication, is often exacerbated by
glucolipotoxicity. The potential benefits of mulberry leaf extract (MLE) and its primary …

Alterations during development of metabolic key organs such as the endocrine pancreas
affect the phenotype later in life. There is evidence that in utero or perinatal exposure to …

A re-examination of the mechanism controlling eating, locomotion, and metabolism prompts
formulation of a new explanatory model containing five features: a coordinating joint role of …