Metabolomics in cancer research and emerging applications in clinical oncology

DR Schmidt, R Patel, DG Kirsch… - CA: a cancer journal …, 2021 - Wiley Online Library
Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Comprehensive metabolomics expands precision medicine for triple-negative breast cancer

Y Xiao, D Ma, YS Yang, F Yang, JH Ding, Y Gong… - Cell research, 2022 - nature.com
Metabolic reprogramming is a hallmark of cancer. However, systematic characterizations of
metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the …

Mechanisms and implications of metabolic heterogeneity in cancer

J Kim, RJ DeBerardinis - Cell metabolism, 2019 - cell.com
Tumors display reprogrammed metabolic activities that promote cancer progression. We
currently possess a limited understanding of the processes governing tumor metabolism in …

Cancer biomarkers and their biosensors: A comprehensive review

H Khan, MR Shah, J Barek, MI Malik - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
The article starts with a brief history of discovery of cancer biomarkers followed by statistical
data on published cancer biomarkers detection strategies in the last decade to demonstrate …

Enzyme‐encapsulated protein trap engineered metal–organic framework‐derived biomineral probes for non‐invasive prostate cancer surveillance

Z Yu, J Tang, H Gong, Y Gao, Y Zeng… - Advanced Functional …, 2023 - Wiley Online Library
A paper‐based naked‐eye recognition assay with enzyme‐encapsulated protein
engineered metal–organic framework‐derived biominerals is developed for direct …

One-carbon metabolism in health and disease

GS Ducker, JD Rabinowitz - Cell metabolism, 2017 - cell.com
One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …

Metabolomics: beyond biomarkers and towards mechanisms

CH Johnson, J Ivanisevic, G Siuzdak - Nature reviews Molecular cell …, 2016 - nature.com
Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …

Non-invasive biomarkers for early detection of breast cancer

J Li, X Guan, Z Fan, LM Ching, Y Li, X Wang, WM Cao… - Cancers, 2020 - mdpi.com
Simple Summary Early diagnosis of breast cancer greatly increases the chance of cure and
survival from the disease. The mammogram is widely used for early detection of breast …

Precision medicine: disease subtyping and tailored treatment

RC Wang, Z Wang - Cancers, 2023 - mdpi.com
Simple Summary The genomics-based concept of precision medicine began to emerge
following the completion of the Human Genome Project. In contrast to evidence-based …