Preterm newborns are exposed to several risk factors for developing brain injury. Clinical
studies have suggested that the presence of intrauterine infection is a consistent risk factor …

(L-) tryptophan is metabolized via the kynurenine pathway into several kynurenine
metabolites with distinct functions. Dysfunction of the kynurenine pathway can lead to …

Nocturnal temperature is observed increasing with global warming. However, evidence on
night-time non-optimal temperature on the risk of preterm birth (PTB) is limited, and the …

The biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT) is a chemical messenger
widely distributed in the brain and various other organs. Its homeostasis is maintained by the …

Selective serotonin reuptake inhibitors (SSRIs) for treatment of prenatal maternal depression
have been associated with neonatal neurobehavioral disturbances, though the molecular …

Maternal immune activation during pregnancy is a risk factor for offspring neuropsychiatric
disorders. Among the mechanistic pathways by which maternal inflammation can affect fetal …

Epidemiological studies have shown that prenatal triphenyl phosphate (TPhP) exposure is
related to abnormal neurobehavior in children. However, the neurodevelopmental toxicity of …

Preterm birth is a major challenge in pregnancy worldwide. Prematurity is the leading cause
of death in infants and may result in severe complications. Nearly half of preterm births are …

The first trimester of pregnancy ranks high in priority when minimizing harmful exposures,
given the wide-ranging types of organogenesis occurring between 4-and 12-weeks' …

Introduction: Tryptophan is the precursor of kynurenine pathway (KP) metabolites which
regulate immune tolerance, energy metabolism, and vascular tone. Since these processes …