Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both
endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local …

▪ Abstract The matrix metalloproteinases (MMPs) constitute a multigene family of over 25
secreted and cell surface enzymes that process or degrade numerous pericellular …

In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell
activity in various ways. By sequestering IGFs away from the type I IGF receptor, they may …

Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily* | Endocrine Reviews | Oxford
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The biological roles of the matrix metalloproteinases (MMPs) have been traditionally
associated with the degradation and turnover of most of the components of the extracellular …

Insulin‐like growth factors (IGFs) are essential for growth and survival that suppress
apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in …

The vascular insulin-like growth factor (IGF)-1 system includes the IGFs, the IGF-1 receptor
(IGF-1R), and multiple binding proteins. This growth factor system exerts multiple …

Enzymatic proteolysis of cell surface proteins and extracellular matrix (ECM) is critical for
tissue homeostasis and cell signaling. These proteolytic activities are mediated …

The insulin-like growth factor (IGF)-binding proteins (IGFBPs) are a family of six homologous
proteins with high binding affinity for IGF-I and IGF-II. Information from NMR and …

The extracellular matrix is not merely a passive structure. In the past few years, it has
emerged that the matrix is a dynamic action zone that functions to instruct cellular …