Molecular and cellular insights into the development of uterine fibroids
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …
Pathogenomics of uterine fibroids development
VS Baranov, NS Osinovskaya… - International journal of …, 2019 - mdpi.com
We review recent studies dealing with the molecular genetics and basic results of omics
analysis of uterine leiomyoma (LM)—a common benign muscle tumor of the uterus. Whole …
analysis of uterine leiomyoma (LM)—a common benign muscle tumor of the uterus. Whole …
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis
CS Gallagher, N Mäkinen, HR Harris… - Nature …, 2019 - nature.com
Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract
and primary cause for hysterectomy, leading to considerable morbidity and high economic …
and primary cause for hysterectomy, leading to considerable morbidity and high economic …
Candidate genes for age at menarche are associated with uterine leiomyoma
I Ponomarenko, E Reshetnikov, A Polonikov… - Frontiers in …, 2021 - frontiersin.org
Age at menarche (AAM) is an important marker of the pubertal development and function of
the hypothalamic–pituitary–ovarian system. It was reported as a possible factor for a risk of …
the hypothalamic–pituitary–ovarian system. It was reported as a possible factor for a risk of …
Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types
Uterine fibroids (UF), that can disrupt normal uterine function and cause significant physical
and psychological health problems, are observed in nearly 70% of women of reproductive …
and psychological health problems, are observed in nearly 70% of women of reproductive …
Deficient H2A. Z deposition is associated with genesis of uterine leiomyoma
DG Berta, H Kuisma, N Välimäki, M Räisänen, M Jäntti… - Nature, 2021 - nature.com
One in four women suffers from uterine leiomyomas (ULs)—benign tumours of the uterine
wall, also known as uterine fibroids—at some point in premenopausal life. ULs can cause …
wall, also known as uterine fibroids—at some point in premenopausal life. ULs can cause …
Epigenomic and enhancer dysregulation in uterine leiomyomas
OW Mlodawska, P Saini, JB Parker… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the
most common benign gynecological tumors and are found in women of reproductive and …
most common benign gynecological tumors and are found in women of reproductive and …
Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
Despite the high lethality of colorectal cancers (CRCs), only a limited number of genetic risk
factors are identified. The mammalian ssDNA-binding protein complex CTC1-STN1-TEN1 …
factors are identified. The mammalian ssDNA-binding protein complex CTC1-STN1-TEN1 …
[HTML][HTML] Uterine fibroids—Causes, impact, treatment, and lens to the African perspective
N Sefah, S Ndebele, L Prince, E Korasare… - Frontiers in …, 2023 - frontiersin.org
Leiomyomas, or uterine fibroids as they are commonly known, are mostly seen in women of
reproductive age. However, they can go undetected in most women, and approximately 25 …
reproductive age. However, they can go undetected in most women, and approximately 25 …
CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection
RK Jaiswal, KH Lei, M Chastain, Y Wang… - Nature …, 2023 - nature.com
Keeping replication fork stable is essential for safeguarding genome integrity; hence, its
protection is highly regulated. The CTC1-STN1-TEN1 (CST) complex protects stalled forks …
protection is highly regulated. The CTC1-STN1-TEN1 (CST) complex protects stalled forks …