Molecular and cellular insights into the development of uterine fibroids

A Machado-Lopez, C Simón, A Mas - International journal of molecular …, 2021 - mdpi.com
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

Pathogenomics of uterine fibroids development

VS Baranov, NS Osinovskaya… - International journal of …, 2019 - mdpi.com
We review recent studies dealing with the molecular genetics and basic results of omics
analysis of uterine leiomyoma (LM)—a common benign muscle tumor of the uterus. Whole …

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

CS Gallagher, N Mäkinen, HR Harris… - Nature …, 2019 - nature.com
Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract
and primary cause for hysterectomy, leading to considerable morbidity and high economic …

Candidate genes for age at menarche are associated with uterine leiomyoma

I Ponomarenko, E Reshetnikov, A Polonikov… - Frontiers in …, 2021 - frontiersin.org
Age at menarche (AAM) is an important marker of the pubertal development and function of
the hypothalamic–pituitary–ovarian system. It was reported as a possible factor for a risk of …

Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types

K Buyukcelebi, AJ Duval, F Abdula, H Elkafas… - Nature …, 2024 - nature.com
Uterine fibroids (UF), that can disrupt normal uterine function and cause significant physical
and psychological health problems, are observed in nearly 70% of women of reproductive …

Deficient H2A. Z deposition is associated with genesis of uterine leiomyoma

DG Berta, H Kuisma, N Välimäki, M Räisänen, M Jäntti… - Nature, 2021 - nature.com
One in four women suffers from uterine leiomyomas (ULs)—benign tumours of the uterine
wall, also known as uterine fibroids—at some point in premenopausal life. ULs can cause …

Epigenomic and enhancer dysregulation in uterine leiomyomas

OW Mlodawska, P Saini, JB Parker… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the
most common benign gynecological tumors and are found in women of reproductive and …

Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair

DD Nguyen, E Kim, NT Le, X Ding, RK Jaiswal… - Science …, 2023 - science.org
Despite the high lethality of colorectal cancers (CRCs), only a limited number of genetic risk
factors are identified. The mammalian ssDNA-binding protein complex CTC1-STN1-TEN1 …

[HTML][HTML] Uterine fibroids—Causes, impact, treatment, and lens to the African perspective

N Sefah, S Ndebele, L Prince, E Korasare… - Frontiers in …, 2023 - frontiersin.org
Leiomyomas, or uterine fibroids as they are commonly known, are mostly seen in women of
reproductive age. However, they can go undetected in most women, and approximately 25 …

CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection

RK Jaiswal, KH Lei, M Chastain, Y Wang… - Nature …, 2023 - nature.com
Keeping replication fork stable is essential for safeguarding genome integrity; hence, its
protection is highly regulated. The CTC1-STN1-TEN1 (CST) complex protects stalled forks …