A perspective of epigenetic regulation in radiotherapy

Q Peng, K Weng, S Li, R Xu, Y Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
Radiation therapy (RT) has been employed as a tumoricidal modality for more than 100
years and on 470,000 patients each year in the United States. The ionizing radiation causes …

Nrf2/p-Fyn/ABCB1 axis accompanied by p-Fyn nuclear accumulation plays pivotal roles in vinorelbine resistance in non-small cell lung cancer

S Tamari, T Menju, T Toyazaki… - Oncology …, 2022 - spandidos-publications.com
Adjuvant cisplatin-vinorelbine is a standard therapy for stage II/III lung cancer. However, a
poor survival rate of patients with lung cancer is attributed to vinorelbine resistance arising …

Bioengineering tools for probing intracellular events in T lymphocytes

X Zhang, CF Mariano, Y Ando… - WIREs mechanisms of …, 2021 - Wiley Online Library
T lymphocytes are the central coordinator and executor of many immune functions. The
activation and function of T lymphocytes are mediated through the engagement of cell …

[HTML][HTML] Enabling versatile control of molecular activity with small molecules and light

K Zhang, V Krishnamurthy - Journal of molecular biology, 2020 - ncbi.nlm.nih.gov
Cell function is shaped by signaling events comprising complex macromolecular
interactions. An emerging view is that the signaling outcome depends not only on the …