Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

BACKGROUND Blood and lymphatic vessel networks form two arms of the vertebrate
cardiovascular system that play complementary roles in body homeostasis maintenance and …

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …

Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel
expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby …

Endothelial cells are a constitutive part of the heart and vasculature and form a crucial link
between the cardiovascular system and the immune system. Besides their commonly …

Piezo1 ion channels are mediators of mechanotransduction in several cell types including
the vascular endothelium, renal tubular cells and erythrocytes. Gain-of-function mutations in …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

The mammalian intestine is richly supplied with lymphatic vasculature, which has functions
ranging from maintenance of interstitial fluid balance to transport of antigens, antigen …

Forces acting on cells govern many important regulatory events during development, normal
physiology, and disease processes. Integrin-mediated adhesions, which transmit forces …