[HTML][HTML] From molecules to genomic variations: Accelerating genome analysis via intelligent algorithms and architectures

M Alser, J Lindegger, C Firtina, N Almadhoun… - Computational and …, 2022 - Elsevier
We now need more than ever to make genome analysis more intelligent. We need to read,
analyze, and interpret our genomes not only quickly, but also accurately and efficiently …

GenStore: A high-performance in-storage processing system for genome sequence analysis

N Mansouri Ghiasi, J Park, H Mustafa, J Kim… - Proceedings of the 27th …, 2022 - dl.acm.org
Read mapping is a fundamental step in many genomics applications. It is used to identify
potential matches and differences between fragments (called reads) of a sequenced …

GenStore: A High-Performance and Energy-Efficient In-Storage Computing System for Genome Sequence Analysis

NM Ghiasi, J Park, H Mustafa, J Kim, A Olgun… - arXiv preprint arXiv …, 2022 - arxiv.org
Read mapping is a fundamental, yet computationally-expensive step in many genomics
applications. It is used to identify potential matches and differences between fragments …

Going from molecules to genomic variations to scientific discovery: Intelligent algorithms and architectures for intelligent genome analysis

M Alser, J Lindegger, C Firtina, N Almadhoun… - arXiv preprint arXiv …, 2022 - arxiv.org
We now need more than ever to make genome analysis more intelligent. We need to read,
analyze, and interpret our genomes not only quickly, but also accurately and efficiently …

Count2multiply: Reliable in-memory high-radix counting

JPC de Lima, BF Morris III, AA Khan, J Castrillon… - arXiv preprint arXiv …, 2024 - arxiv.org
Big data processing has exposed the limits of compute-centric hardware acceleration due to
the memory-to-processor bandwidth bottleneck. Consequently, there has been a shift …

Hardware Acceleration of DNA Read Alignment Programs: Challenges and Opportunities

PB Daniel, CA Ricardo, AB Ignacio, PO Miguel - Fractals, 2023 - World Scientific
The alignment or mapping of Deoxyribonucleic Acid (DNA) reads produced by the new
massively parallel sequencing machines is a fundamental initial step in the DNA analysis …

Co-design for energy efficient and fast genomic search: interleaved bloom filter on FPGA

M Knaust, E Seiler, K Reinert, T Steinke - Proceedings of the 2022 ACM …, 2022 - dl.acm.org
Next-Generation Sequencing technologies generate a vast and exponentially increasing
amount of sequence data. The Interleaved Bloom Filter (IBF) is a novel indexing data …

GenStore: In-Storage Filtering of Genomic Data for High-Performance and Energy-Efficient Genome Analysis

NM Ghiasi, J Park, H Mustafa, J Kim… - 2022 IEEE Computer …, 2022 - ieeexplore.ieee.org
Genome sequence analysis, which analyzes the DNA sequences of organisms, is important
for many applications in personalized medicine 1–8, outbreak tracing 9–14, and …

GenoMiX: Accelerated Simultaneous Analysis of Human Genomics, Microbiome Metagenomics, and Viral Sequences

T Zhang, A González, N Moshiri… - … Circuits and Systems …, 2023 - ieeexplore.ieee.org
Personalized medicine tailors treatments based on the individual characteristics of each
patient. Recent work targets comprehensive analysis of patient samples that contain human …

Efficient Memory Layout for Pre-Alignment Filtering of Long DNA Reads Using Racetrack Memory

AA Khan, F Hameed, T Shahroodi… - IEEE Computer …, 2024 - ieeexplore.ieee.org
DNA sequence alignment is a fundamental and computationally expensive operation in
bioinformatics. Researchers have developed pre-alignment filters that effectively reduce the …