Infection with Mycobacterium ulcerans results in a necrotising skin disease known as a
Buruli ulcer, the pathology of which is directly linked to the bacterial production of the toxin …

Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis
reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent …

The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum
membrane that is required for secretion of soluble proteins and production of many …

The cytopathic effects of Zika virus (ZIKV) are poorly characterized. Innate immunity controls
ZIKV infection and disease in most infected patients through mechanisms that remain to be …

Mycolactone, an immunosuppressive macrolide released by the human pathogen
Mycobacterium ulcerans, was previously shown to impair Sec61-dependent protein …

Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy,
but attempts to target essential protein biogenesis factors have been hampered by …

Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with
single-digit nanomolar potency. However, its biological and pharmacological properties …

Infection of subcutaneous tissue with Mycobacterium ulcerans can lead to chronic skin
ulceration known as Buruli ulcer. The pathogenesis of this neglected tropical disease is …

Proteins targeted to the secretory pathway start their intracellular journey by being
transported across biological membranes such as the endoplasmic reticulum (ER). A central …

Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against
human cancer cells and a unique selectivity profile. Despite promising antitumor activity, the …