Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

As people age, iron deposits in different areas of the brain may impair normal cognitive
function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the …

Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Alzheimer's disease (AD), the most common type of senile dementia, includes the complex
pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p …

Saito et al developed a novel amyloid precursor protein (APP) knock-in mouse model (APP
NL-GF) for Alzheimer's disease (AD) to overcome the problem of overexpression of APP in …

Iron is an essential trace element required for important brain functions including oxidative
metabolism, synaptic plasticity, myelination, and the synthesis of neurotransmitters …