Engineering cellular metabolism

J Nielsen, JD Keasling - Cell, 2016 - cell.com
Metabolic engineering is the science of rewiring the metabolism of cells to enhance
production of native metabolites or to endow cells with the ability to produce new products …

Systems metabolic engineering of microorganisms for food and cosmetics production

KR Choi, SY Lee - Nature Reviews Bioengineering, 2023 - nature.com
The demand for sustainable and environmentally friendly sources of foods and cosmetics is
increasing owing to concerns about the rapid growth of the global population and climate …

[HTML][HTML] Fermentation-enabled wellness foods: A fresh perspective

H Xiang, D Sun-Waterhouse, GIN Waterhouse… - Food Science and …, 2019 - Elsevier
Fermented foods represent an important segment of current food markets, especially
traditional or ethnic food markets. The demand for efficient utilization of agrowastes, together …

Systems strategies for developing industrial microbial strains

SY Lee, HU Kim - Nature biotechnology, 2015 - nature.com
Industrial strain development requires system-wide engineering and optimization of cellular
metabolism while considering industrially relevant fermentation and recovery processes. It …

Biorefineries for the production of top building block chemicals and their derivatives

S Choi, CW Song, JH Shin, SY Lee - Metabolic engineering, 2015 - Elsevier
Due to the growing concerns on the climate change and sustainability on petrochemical
resources, DOE selected and announced the bio-based top 12 building blocks and …

Systems metabolic engineering strategies: integrating systems and synthetic biology with metabolic engineering

KR Choi, WD Jang, D Yang, JS Cho, D Park… - Trends in …, 2019 - cell.com
Metabolic engineering allows development of microbial strains efficiently producing
chemicals and materials, but it requires much time, effort, and cost to make the strains …

Structure, function, and mechanism of the nickel metalloenzymes, CO dehydrogenase, and acetyl-CoA synthase

M Can, FA Armstrong, SW Ragsdale - Chemical reviews, 2014 - ACS Publications
1.1. Research on Catalytic Reactions Involving CO and CO2: Relationship to Energy, the
Environment, Biogeochemistry, Toxicology, Health, and Technology The major …

Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol

H Yim, R Haselbeck, W Niu, C Pujol-Baxley… - Nature chemical …, 2011 - nature.com
Butanediol (BDO) is an important commodity chemical used to manufacture over 2.5 million
tons annually of valuable polymers, and it is currently produced exclusively through …

Amino acids production focusing on fermentation technologies–A review

M D'Este, M Alvarado-Morales, I Angelidaki - Biotechnology advances, 2018 - Elsevier
Amino acids are attractive and promising biochemicals with market capacity requirements
constantly increasing. Their applicability ranges from animal feed additives, flavour …

Systems metabolic engineering of microorganisms for natural and non-natural chemicals

JW Lee, D Na, JM Park, J Lee, S Choi… - Nature chemical biology, 2012 - nature.com
Growing concerns over limited fossil resources and associated environmental problems are
motivating the development of sustainable processes for the production of chemicals, fuels …