Exosomes are natural nanovesicles excreted by many cells for intercellular communication
and for transfer of materials including proteins, nucleic acids and even synthetic therapeutic …

Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

Huntington's disease (HD) is a neurodegenerative disorder that manifests with movement
dysfunction. The expression of mutant Huntingtin (mHTT) disrupts the functions of brain …

Shigella bacteria invade macrophages and epithelial cells and following internalization lyse
the phagosome and escape to the cytoplasm. Galectin‐3, an abundant protein in …

Mucins are high-molecular weight epithelial glycoproteins with a high content of clustered
oligosaccharides O-glycosidically linked to tandem repeat peptides rich in threonine, serine …

Reticulocytes release small membrane vesicles termed exosomes during their maturation
into erythrocytes. Exosomes are intraluminal vesicles of multivesicular endosomes released …

Galectin-3 has been suspected of modulating cell to extracellular matrix interactions in a
novel fashion ever since it was first described. However, the rapid accumulation of research …

Discovery of glycan‐competitive galectin‐3‐binding compounds that attenuate lung fibrosis
in a murine model and that block intracellular galectin‐3 accumulation at damaged vesicles …

Galectin-3 is a 31 kDa member of a growing family of β-galactosidebinding animal lectins.
This protein is expressed in a variety of tissues and cell types and is mainly found in the …

The causes of metastasis remain elusive despite vast information on cancer cells. We posit
that cancer cell fusion with macrophages or other migratory bone marrow-derived cells …