BACKGROUND: Glutathione (GSH) is present in all mammalian tissues as the most
abundant non-protein thiol that defends against oxidative stress. GSH is also a key …

Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver diseases, and is closely
related to metabolic syndrome and its related conditions, diabetes mellitus and dyslipidemia …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

Cholestasis is a multifaceted clinical complication. Obstructive jaundice induced by bile duct
ligation (BDL) is known as an animal model to investigate cholestasis and its associated …

It has been well established that S-adenosyl-L-methionine (SAMe) is the principal methyl
donor in methyltransferase reactions and that SAMe supplementation restores hepatic …

Glutathione (GSH), a tripeptide that is present in all mammalian tissues, is especially highly
concentrated in the liver. GSH synthesis occurs via two adenosine triphosphate (ATP) …

Background. A new medical approach to primary biliary cirrhosis (PBC) has been desired.
We investigated the feasibility of using combination ursodeoxycholic acid (UDCA) …

OBJECTIVE: To determine the effect of ursodeoxycholic acid (UDCA) in very-low-birth-
weight (VLBW) infants with parenteral nutrition-associated cholestasis (PNAC). STUDY …

Copper is an essential trace element, however, excess copper is harmful to human health.
Excess copper-derived oxidants contribute to the progression of Wilson disease, and …

Aliment Pharmacol Ther 2011; 34: 1185–1192 Summary Background Ursodeoxycholic acid
(UDCA) in a dose of 28–30 mg/kg/day increases the likelihood of clinical deterioration of …