Bone grafting is involved in virtually every procedure in reconstructive orthopaedic surgery.
Although autologous bone grafts have excellent biologic and mechanical properties …

Aim: The use of recombinant human platelet-derived growth factor–BB (rhPDGF) has
received Food and Drug Administration approval for the treatment of periodontal and …

Large bony defects and non-unions are still a complication in trauma and orthopedic
surgery. Treatment strategies include the use of autogenous materials (iliac crest), allogenic …

Objectives Since the original description of osteoinduction in the early 20th century, the
study and development of innovative biomaterials has emerged. Recently, novel synthetic …

The gold standard material for bone regeneration is still autologous bone, a mesenchymal
tissue that consists mainly of extracellular matrix (ECM)(90% v/v) and little cellular content …

Besides autografts, allografts, and synthetic materials, demineralized bone matrix (DBM) is
used for bone defect filling and treatment of non‐unions. Different DBM formulations are …

Study Design. Enzyme-linked immunosorbent assay was used to detect bone
morphogenetic proteins (BMPs) 2, 4, and 7 in 9 commercially available (“off the shelf”) …

Clinically, orthodontic tooth movement (OTM) across the narrow alveolar ridge area
inevitably entails some adverse reactions such as limited movement and periodontal tissue …

Osteoinductive of demineralized bone matrix has been attributed to bone morphogenetic
proteins (BMP). Other growth factors, including insulin-like growth factor-l (ICF-I) and …

Background: Platelet-derived growth factor (PDGF) has been proposed as a therapeutic
agent to promote bone-healing. The purpose of this study was to examine the effect of PDGF …