The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs,
zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the …

Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of
cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of …

Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in
metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in …

Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress
the oncogenic transformation of cells by Ras. Rap1 is activated by several extracellular …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

Wnt/β-Catenin signaling plays key roles in tissue homeostasis and cell fate decisions in
embryonic and post-embryonic development across the animal kingdom. As a result …

More is becoming known about so-called noncanonical Wnt pathways that signal
independently of β-catenin. Here we review recent developments in both the functions and …

Tumors of the colorectum are amongst the most comof the new discoveries that are relevant
to colorectal mon human neoplasms. Approximately 5% of the Westcancer in humans have …