Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …

Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …

Background Breast cancer is currently the most common neoplasm diagnosed in women
globally. There is a growing body of evidence to suggest that human papillomavirus (HPV) …

Cancer and related diseases are the second leading cause of death worldwide. The human
papillomavirus (HPV) is an infectious agent that can be spread mainly through sexual …

The BRCA1 protein, one of the major players responsible for DNA damage response has
recently been linked to Alzheimer's disease (AD). Using primary fibroblasts and neurons …

Cancer is a complex and dynamic disease. The “hallmarks of cancer” were proposed by
Hanahan and Weinberg (2000) as a group of biological competencies that human cells …

Multiple myeloma (MM) treatment regimens have vastly improved since the introduction of
immunomodulators, proteasome inhibitors, and anti-CD38 monoclonal antibodies; however …

Background Breast Cancer (BC) stands out as the widely prevalent malignancy among all
the types of cancer affecting women worldwide. There is significant evidence that the …

The breast cancer type 1 susceptibility protein (BRCA1) and its partner–the BRCA1-
associated RING domain protein 1 (BARD1)–are key players in a plethora of fundamental …

BRCA1 is one of the most frequently-mutated tumor suppressor genes in ovarian and breast
cancers. Loss of BRCA1 triggers homologous recombination (HR) repair deficiency …