An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies

A D'Alessandro, AG Kriebardis, S Rinalducci… - …, 2015 - Wiley Online Library
Red blood cell (RBC) aging in the blood bank is characterized by the accumulation of a
significant number of biochemical and morphologic alterations. Recent mass spectrometry …

[HTML][HTML] Blood microvesicles: from proteomics to physiology

JD Tissot, G Canellini, O Rubin… - Translational …, 2013 - Elsevier
Phospholipid vesicles of less than 1 μm are present in blood in physiological state and their
concentration may vary under pathological conditions. Various names such as exosomes …

Alterations of red blood cell metabolome during cold liquid storage of erythrocyte concentrates in CPD–SAGM

F Gevi, A D'Alessandro, S Rinalducci, L Zolla - Journal of proteomics, 2012 - Elsevier
Erythrocyte concentrates for transfusion purposes represent a life-saving therapeutics of
primary relevance in the clinical setting. However, efforts have been continuously proposed …

Glucose 6-phosphate dehydrogenase deficient subjects may be better “storers” than donors of red blood cells

VL Tzounakas, AG Kriebardis, HT Georgatzakou… - Free Radical Biology …, 2016 - Elsevier
Storage of packed red blood cells (RBCs) is associated with progressive accumulation of
lesions, mostly triggered by energy and oxidative stresses, which potentially compromise the …

Biophysical and biochemical markers of red blood cell fragility

A Orbach, O Zelig, S Yedgar, G Barshtein - Transfusion Medicine and …, 2017 - karger.com
Summary Background: Red blood cells (RBCs) undergo a natural aging process occurring
in the blood circulation throughout the RBC lifespan or during routine cold storage in the …

[HTML][HTML] Involvement of calcium, reactive oxygen species, and ATP in hexavalent chromium-induced damage in red blood cells

R Zhang, Y Xiang, Q Ran, X Deng, Y Xiao… - Cellular Physiology and …, 2014 - karger.com
Aim: The aim of this study was to investigate the mechanisms of Cr 6+-induced red blood
cells (RBCs) damage. Methods: The effect of Cr 6+ exposure on RBCs was evaluated by …

Erythrocyte's aging in microgravity highlights how environmental stimuli shape metabolism and morphology

S Dinarelli, G Longo, G Dietler, A Francioso, L Mosca… - Scientific reports, 2018 - nature.com
The determination of the function of cells in zero-gravity conditions is a subject of interest in
many different research fields. Due to their metabolic unicity, the characterization of the …

Protect, repair, destroy or sacrifice: a role of oxidative stress biology in inter-donor variability of blood storage?

A D'Alessandro, KC Hansen… - Blood …, 2018 - pmc.ncbi.nlm.nih.gov
Red blood cells (RBCs) have been historically regarded as a critical model to investigate
cellular and oxidant stress biology. First of all, they are constantly exposed to oxidant stress …

Storage-induced damage to red blood cell mechanical properties can be only partially reversed by rejuvenation

G Barshtein, A Gural, N Manny, O Zelig… - Transfusion medicine …, 2014 - karger.com
Background: The storage of red blood cells (RBC) is associated with impairment of their
properties that can induce a circulatory risk to recipients. In a preceding study (2009), we …

Surprising structural and functional properties of Favism erythrocytes are linked to special metabolic regulation: a cell aging study

S Dinarelli, G Longo, S Germanova-Taneva… - International Journal of …, 2022 - mdpi.com
Favism uniquely arises from a genetic defect of the Glucose-6 Phosphate Dehydrogenase
(G6PD) enzyme and results in a severe reduction of erythrocytes'(RBCs) reducing power …