Mice homozygous for the scid mutation (scid mice) are severely deficient in functional B and
T lymphocytes. The mutation appears to impair the recombination of antigen receptor genes …

Most human lymphoid malignancies preserve a pattern of gene expression reflecting their
proliferative activity and the developmental level of clonal expansion and maturation arrest …

In a screen for transcriptional regulators that control differentiation into the T cell lineage, a
complementary DNA was isolated encoding a zinc finger protein (Ikaros) related to the …

We have characterized a pre-Golgi, proteolytic pathway for rapid degradation of newly
synthesized T cell receptor (TCR) subunits which is insensitive to drugs that block lysosomal …

During early fetal development, T cell precursors home from fetal yolk sac and liver to the
epithelial thymic rudiment. From cells that initially colonize the thymus arise mature T cells …

The human T cell-specific transcription factor TCF-1 alpha plays a key role in the tissue-
specific activation of the T cell receptor (TCR) C alpha enhancer and binds to pyrimidine-rich …

Using multidimensional flow cytometry we have defined and quantified the human T-cell
differentiation pathway, focusing on those events occurring among the most immature …

During the last decade the classification of lymphoproliferative diseases and related
disorders has been improved by the application of immunologic marker analysis [l-7] …

The expression of cytoplasmic CD3 (CyCD3) was analyzed in 45 leukemias, five thymus cell
samples, five peripheral blood (PB) samples, and ten cell lines. All T cell acute …

Cloned blood lymphocytes that do not express the α-and β-chains of the T-cell receptor
show MHC-unrestricted cytotoxicity. These cells carry the γ-protein, disulphide-linked either …