The current landscape of NKT cell immunotherapy and the hills ahead

A Nelson, JD Lukacs, B Johnston - Cancers, 2021 - mdpi.com
Simple Summary Natural killer T (NKT) cells are a subset of lipid-reactive T cells that
enhance anti-tumor immunity. While preclinical studies have shown NKT cell …

CAR-NKT cell therapy: a new promising paradigm of cancer immunotherapy

K Hadiloo, S Tahmasebi, A Esmaeilzadeh - Cancer Cell International, 2023 - Springer
Today, cancer treatment is one of the fundamental problems facing clinicians and
researchers worldwide. Efforts to find an excellent way to treat this illness continue, and new …

Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects

AJ Guillot, M Martínez‐Navarrete… - Wiley …, 2023 - Wiley Online Library
Transdermal delivery of drugs offers an interesting alternative for the administration of
molecules that present certain troubles when delivered by the oral route. It can produce …

Artificial intelligence in nanomedicine

D Ho, P Wang, T Kee - Nanoscale Horizons, 2019 - pubs.rsc.org
The field of nanomedicine has made substantial strides in the areas of therapeutic and
diagnostic development. For example, nanoparticle-modified drug compounds and imaging …

Toll-like receptor-targeted anti-tumor therapies: Advances and challenges

Y Yang, H Li, C Fotopoulou, P Cunnea… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …

The role of toll-like receptor agonists and their nanomedicines for tumor immunotherapy

L Huang, X Ge, Y Liu, H Li, Z Zhang - Pharmaceutics, 2022 - mdpi.com
Toll-like receptors (TLRs) are a class of pattern recognition receptors that play a critical role
in innate and adaptive immunity. Toll-like receptor agonists (TLRa) as vaccine adjuvant …

Carbohydrate conjugates in vaccine developments

S Lang, X Huang - Frontiers in Chemistry, 2020 - frontiersin.org
Vaccines are powerful tools that can activate the immune system for protection against
various diseases. As carbohydrates can play important roles in immune recognition, they …

[HTML][HTML] Engineering customized nanovaccines for enhanced cancer immunotherapy

J Guo, C Liu, Z Qi, T Qiu, J Zhang, H Yang - Bioactive Materials, 2024 - Elsevier
Nanovaccines have gathered significant attention for their potential to elicit tumor-specific
immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines …

cGAMP-adjuvanted multivalent influenza mRNA vaccines induce broadly protective immunity through cutaneous vaccination in mice

W Zhu, L Wei, C Dong, Y Wang, J Kim, Y Ma… - … Therapy-Nucleic Acids, 2022 - cell.com
Increasing preclinical and clinical results have demonstrated that mRNA vaccines efficiently
prevent infectious diseases and are safe in animal models and humans. In this study, we …

Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases

X Jin, GY Yang - Progress in Lipid Research, 2023 - Elsevier
Glycosphingolipids (GSLs) are major amphiphilic glycolipids present on the surface of living
cell membranes. They have important biological functions, including maintaining plasma …