Myasthenia gravis (MG) is a chronic, fluctuating, antibody-mediated autoimmune disorder
directed against the post-synaptic neuromuscular junctions of skeletal muscles, resulting in …

Autoimmune diseases (ADs) represent a heterogenous group of complex diseases with
increasing incidence in Western countries and are a major cause of morbidity …

Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary treatment modality used to
treat haematological malignancies. Lymphocytes are engineered to produce CARs directed …

Autoimmune disease results from the immune response against self-antigens, while cancer
develops when the immune system does not respond to malignant cells. Thus, for years …

T cells are critical orchestrators of the adaptive immune response that optimally eliminate a
specific pathogen. Aberrant T-cell development and function are implicated in a broad range …

Rheumatoid arthritis is an immune‐mediated inflammatory disease in which fibroblasts
contribute to both joint damage and inflammation. Fibroblasts are a major cell constituent of …

Primary membranous nephropathy (pMN) is an auto-immune disease characterized by auto-
antibodies targeting podocyte antigens resulting in activation of complement and damage to …

Ex vivo expansion of T lymphocytes is a central process in the generation of cellular
therapies targeted at tumors and other disease-relevant structures, which currently cannot …

For nearly three decades, chimeric antigen receptors (CARs) have captivated the interest of
researchers seeking to find novel immunotherapies to treat cancer. CARs were first …

Regulatory T cells (Tregs) have the role of regulating self-tolerance, and suppressing
immune responses. Defects in Treg function and number can lead to in loss of tolerance or …