[HTML][HTML] Contaminants of emerging concern (CECs) and male reproductive health: challenging the future with a double-edged sword

D Marcu, S Keyser, L Petrik, S Fuhrimann, L Maree - Toxics, 2023 - mdpi.com
Approximately 9% of couples are infertile, with half of these cases relating to male factors.
While many cases of male infertility are associated with genetic and lifestyle factors …

[HTML][HTML] Using experimental models to decipher the effects of acetaminophen and NSAIDs on reproductive development and health

B Boizet-Bonhoure, S Déjardin, M Rossitto… - Frontiers in …, 2022 - frontiersin.org
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin (acetylsalicylic acid),
diclofenac and ibuprofen (IBU), and analgesic drugs, such as acetaminophen (APAP, or …

Interleukin-1β-induced inflammation and acetaminophen during infancy: Distinct and interactive effects on social-emotional and repetitive behavior in C57BL/6J mice

C Harshaw, AG Warner - Pharmacology Biochemistry and Behavior, 2022 - Elsevier
Acetaminophen (APAP) exposure early in life has been associated with increased risk of
neurodevelopmental disorders in epidemiological studies. In rodent models, early-life APAP …

Maternal administration of acetaminophen affects meiosis through its metabolite NAPQI targeting SIRT7 in fetal oocytes

F Liu, J He, X Chen, R Liu, F Li, Y Geng… - Antioxidants & Redox …, 2024 - liebertpub.com
Aim: Acetaminophen (APAP) is clinically recommended as analgesic and antipyretic among
pregnant women. However, accumulating laboratory evidence shows that the use of APAP …

Sulfasalazine exposure during pregnancy and lactation induces alterations in reproductive behavior in adult female rat offspring

S Forcato, AB de Oliveira Aquino… - Life Sciences, 2022 - Elsevier
Aims Sulfasalazine (SAS) is the first line drug in the treatment of chronic inflammatory bowel
diseases in pregnant women. SAS and its metabolites cross the placenta and can be …

Is paracetamol a neuroendocrine disruptor of the developing sexual brain?

GA Coria-Avila, A de Jesús Guzmán-Montemayor… - Medical …, 2024 - Elsevier
Although paracetamol is considered a safe medication during pregnancy at therapeutic
doses, and despite animal studies showing no negative effects or reporting no adverse …

[HTML][HTML] Assessment of Human Fetuses Undergoing Acute Pain: Validation of the Fetal-7 Scale

LS Bernardes, AM Fernandes, MA Carvalho, J Ottolia… - The Journal of …, 2024 - Elsevier
Improvements in fetal ultrasound have allowed for the diagnosis and treatment of fetal
diseases in the uterus, often through surgery. However, little attention has been drawn to the …

Intrauterine and lactational exposure to paracetamol: Cardiometabolic evaluation in adult female and male offspring

DRBS Novi, CB Vidigal, KF Moura… - Journal of …, 2021 - journals.lww.com
Paracetamol (PAR) is the most common over-the-counter drug recommended by physicians
for treatment of pain and fever during gestation. This drug is not teratogenic, being …

[HTML][HTML] Relaxing effects of paracetamol on uterine spontaneous contraction in rats in vitro

Z Ercan, G Zorlu, Ö Bulmuş, İ Serhatlıoğlu… - Medical …, 2022 - dergipark.org.tr
Aim: Paracetamol is a commonly used drug in acute and chronic pain. It is known that
paracetamol, which is a pain reliever and antipyretic drug, is safe to use during pregnancy …

Evaluation of hepatic and renal effects in rat dams and their offspring after exposure to paracetamol during gestation and lactation

AM de Mello Miyasaki, C Rigobello… - Reproduction …, 2021 - CSIRO Publishing
Paracetamol (PAR) is the analgesic and antipyretic of choice for pregnant and nursing
women. PAR may reach the fetus and/or neonate through the placenta and/or milk and effect …