Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

The fertility and survival of an individual rely on the ability of the periphery to promptly,
effectively, and reproducibly communicate with brain neural networks that control …

At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …

A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

Many neurological disorders are characterised by structural changes in neuronal
connections, ranging from presymptomatic synaptic changes to the loss or rewiring of entire …

Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …

Fertility in mammals is controlled by hypothalamic neurons that secrete gonadotropin-
releasing hormone (GnRH). These neurons differentiate in the olfactory placodes during …

A sparse population of a few hundred primarily hypothalamic neurons forms the hub of a
complex neuroglial network that controls reproduction in mammals by secreting the'master …

Natural fluctuations in physiological conditions require adaptive responses involving rapid
and reversible structural and functional changes in the hypothalamic neuroendocrine …

Gonadotropin releasing hormone (GnRH) neurons originate the nasal placode and migrate
into the brain during prenatal development. Once within the brain, these cells become …