[HTML][HTML] Hallucinogenic potential: a review of psychoplastogens for the treatment of opioid use disorder

MG Hornick, A Stefanski - Frontiers in Pharmacology, 2023 - frontiersin.org
The United States is entering its fourth decade of the opioid epidemic with no clear end in
sight. At the center of the epidemic is an increase in opioid use disorder (OUD), a complex …

Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies

FF Hilal, J Jeanblanc, C Deschamps… - Journal of Neural …, 2024 - Springer
Alcohol use disorder (AUD) is a public health issue that affects millions of people worldwide
leading to physical, mental and socio-economic consequences. While current treatments for …

Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A …

N Liu, F Eshak, F Malhaire, I Brabet… - Journal of Medicinal …, 2024 - ACS Publications
Metabotropic glutamate (Glu) receptors (mGlu receptors) play a key role in modulating
excitatory neurotransmission in the central nervous system (CNS). In this study, we report …

[HTML][HTML] Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective …

M Staudt, N Liu, F Malhaire, Y Doroudian… - European Journal of …, 2024 - Elsevier
The metabotropic glutamate (Glu) receptors (mGluRs) are G-protein coupled receptors,
which play a central role in modulating excitatory neurotransmission in the central nervous …

Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats

JR Reinwald, CN Schmitz, I Skorodumov… - Translational …, 2023 - nature.com
Abstract Alcohol Use Disorder (AUD) adversely affects the lives of millions of people, but still
lacks effective treatment options. Recent advancements in psychedelic research suggest …

Unlocking the Healing Power of Psilocybin: An overview of the Role of Psilocybin Therapy in Major Depressive Disorder, Obsessive-Compulsive Disorder and …

S Szafoni, P Gręblowski, K Grabowska… - Frontiers in …, 2024 - frontiersin.org
Resistance to traditional treatment methods is still a major obstacle in modern psychiatry. As
a result, several studies are currently being conducted to find effective alternatives to …

Modifications épigénétiques dans l'addiction à l'alcool et perspectives thérapeutiques

O Pierrefiche - Bulletin de l'Académie Nationale de Médecine, 2024 - Elsevier
Alcohol consumption is a major public health issue. Patients with Alcohol Use Disorder
(AUD) can benefit from five treatments that preferentially target membrane receptors, but …

Psychédéliques et addictions: réémergence d'une modalité thérapeutique pour le traitement des troubles liés à l'usage de substances

E Kervadec, A Benyamina, B Roméo - L'Information psychiatrique, 2023 - cairn.info
Depuis plus de 20 ans, nous assistons à un renouveau de la médecine psychédélique qui
touche notamment la psychiatrie et l'addictologie. Compte tenu des options thérapeutiques …

Prefrontal Electrophysiological Biomarkers and Mechanism-Based Drug Effects in a Rat Model of Alcohol Addiction

N Bernhardt, B Habelt, D Afanasenkau, C Schwarz… - 2024 - researchsquare.com
Current treatments for alcohol use disorder (AUD) show large heterogeneity in response
and thus limited effectiveness and high relapse rates. A precision medicine approach with …