Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
Snake venoms in drug discovery: Valuable therapeutic tools for life saving
Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact,
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …
The phospholipase A2 superfamily and its group numbering system
RH Schaloske, EA Dennis - … et Biophysica Acta (BBA)-Molecular and Cell …, 2006 - Elsevier
The superfamily of phospholipase A2 (PLA2) enzymes currently consists of 15 Groups and
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …
High-throughput proteomics and in vitro functional characterization of the 26 medically most important elapids and vipers from sub-Saharan Africa
Venomous snakes are important parts of the ecosystem, and their behavior and evolution
have been shaped by their surrounding environments over the eons. This is reflected in their …
have been shaped by their surrounding environments over the eons. This is reflected in their …
[图书][B] Handbook of venoms and toxins of reptiles
SP Mackessy - 2016 - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shopping" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …
Haemostatically active proteins in snake venoms
T Sajevic, A Leonardi, I Križaj - Toxicon, 2011 - Elsevier
Snake venom proteins that affect the haemostatic system can cause (a) lowering of blood
coagulability,(b) damage to blood vessels, resulting in bleeding,(c) secondary effects of …
coagulability,(b) damage to blood vessels, resulting in bleeding,(c) secondary effects of …
The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
Anticoagulant proteins from snake venoms: structure, function and mechanism
RM Kini - Biochemical Journal, 2006 - portlandpress.com
Over the last several decades, research on snake venom toxins has provided not only new
tools to decipher molecular details of various physiological processes, but also inspiration to …
tools to decipher molecular details of various physiological processes, but also inspiration to …
Catalytically Active Snake Venom PLA2 Enzymes: An Overview of Its Elusive Mechanisms of Reaction: Miniperspective
J Castro-Amorim, A Novo de Oliveira… - Journal of Medicinal …, 2023 - ACS Publications
Snake venom-secreted phospholipase A2 (svPLA2) enzymes, both catalytically active and
inactive, are a central component in envenoming. These are responsible for disrupting the …
inactive, are a central component in envenoming. These are responsible for disrupting the …
Proteomic Analysis of Cattle Tick Rhipicephalus (Boophilus) microplus Saliva: A Comparison between Partially and Fully Engorged Females
The cattle tick Rhipicephalus (Boophilus) microplus is one of the most harmful parasites
affecting bovines. Similarly to other hematophagous ectoparasites, R. microplus saliva …
affecting bovines. Similarly to other hematophagous ectoparasites, R. microplus saliva …