In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

The Ccr4‐Not complex is a multisubunit complex present in all eukaryotes that contributes to
regulate gene expression at all steps, from production of messenger RNAs (mRNAs) in the …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Most cellular processes are carried out by multiprotein complexes. The identification and
analysis of their components provides insight into how the ensemble of expressed proteins …

In mammalian cells, the enzymatic pathways involved in cytoplasmic mRNA decay are
incompletely defined. In this study, we have used two approaches to disrupt activities of …

Understanding gene expression control requires defining the molecular and cellular basis of
mRNA turnover. We have previously shown that the human decapping factors hDcp2 and …

Shortening and removal of the 3′ poly (A) tail of mature mRNA by poly (A)-specific 3′
exonucleases (deadenylases) is the initial and often rate-limiting step in mRNA degradation …

The major pathways of mRNA turnover in eukaryotes initiate with shortening of the poly (A)
tail. We demonstrate by several criteria that CCR4 and CAF1 encode critical components of …

The Ccr4–Not complex is a unique, essential and conserved multi-subunit complex that acts
at the level of many different cellular functions to regulate gene expression. Two enzymatic …

The control of mRNA degradation is an important component of the regulation of gene
expression since the steady-state concentration of mRNA is determined both by the rates of …