The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
Mechanisms of action and persistent neuroplasticity by drugs of abuse
ER Korpi, B den Hollander, U Farooq… - Pharmacological …, 2015 - Elsevier
Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …
important for the homeostasis of brain processes and for learning and remembering …
Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis
MD Scofield, PW Kalivas - The Neuroscientist, 2014 - journals.sagepub.com
Addiction is characterized as a chronic relapsing disorder whereby addicted individuals
persistently engage in drug seeking and use despite profound negative consequences. The …
persistently engage in drug seeking and use despite profound negative consequences. The …
Glutamatergic targets for new alcohol medications
Rationale An increasingly compelling literature points to a major role for the glutamate
system in mediating the effects of alcohol on behavior and the pathophysiology of …
system in mediating the effects of alcohol on behavior and the pathophysiology of …
Role of cues and contexts on drug‐seeking behaviour
Environmental stimuli are powerful mediators of craving and relapse in substance‐abuse
disorders. This review examined how animal models have been used to investigate the …
disorders. This review examined how animal models have been used to investigate the …
International union of basic and clinical pharmacology. CXI. Pharmacology, signaling, and physiology of metabotropic glutamate receptors
KJ Gregory, C Goudet, EH Ohlstein - Pharmacological reviews, 2021 - Elsevier
Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …
mGlu5 function in the nucleus accumbens core during the incubation of methamphetamine craving
Many studies have demonstrated that negative allosteric modulators (NAM) of metabotropic
glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction …
glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction …
Effect of novel allosteric modulators of metabotropic glutamate receptors on drug self-administration and relapse: a review of preclinical studies and their clinical …
Results from preclinical rodent studies during the last 20 years implicated glutamate
neurotransmission in different brain regions in drug self-administration and rodent models of …
neurotransmission in different brain regions in drug self-administration and rodent models of …
Negative allosteric modulators of metabotropic glutamate receptors subtype 5 in addiction: a therapeutic window
Background: Abundant evidence at the anatomical, electrophysiological, and molecular
levels implicates metabotropic glutamate receptor subtype 5 (mGluR5) in addiction …
levels implicates metabotropic glutamate receptor subtype 5 (mGluR5) in addiction …
Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma
HD Schmidt, RL Schassburger, LA Guercio… - Journal of …, 2013 - Soc Neuroscience
Recent studies indicate a critical role for metabotropic glutamate receptor 5 (mGluR5) in the
reinstatement of cocaine seeking. However, the signal transduction pathways through which …
reinstatement of cocaine seeking. However, the signal transduction pathways through which …