NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal
proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a …

Background The lumen of the gastrointestinal tract contains many substances produced
from the breakdown of foodstuffs, from salivary, esophageal, intestinal, hepatic, and …

Urolithiasis is one of the most common urologic diseases in industrialized societies. Calcium
oxalate is the predominant component in 70–80% of kidney stones, and small changes in …

Taste transduction molecules, such as Gαgust, and taste receptor families for bitter [taste
receptor type 2 (T2R)], sweet, and umami, have previously been identified in taste buds and …

The development of cardiovascular diseases is often attributable to loss of endothelial
functions of the vascular tissue or to decreased contractile function of the heart muscle …

The colon is believed to absorb NaCl via the coupled operation of apical Na/H exchanger-3
(NHE3) and Cl/HCO3 exchanger SLC26A3 (DRA). Efficient coupling requires that NHE3 …

Solute Carrier Family 26 (SLC26) is a conserved anion transporter family with 10 members
in human (SLC26A1-A11, A10 being a pseudogene). All SLC26 genes except for SLC26A5 …

ABSTRACT SLC26 family members are multifunctional transporters of small anions,
including Cl−, HCO3−, sulfate, oxalate, and formate. Most SLC26 isoforms act as secondary …

Citrobacter rodentium is an attaching and effacing pathogen used as a murine model for
enteropathogenic Escherichia coli. The mucus layers are a complex matrix of molecules …

Luminal isobutyrate, a relatively poor metabolized short-chain fatty acid (SCFA), induces
HCO3 secretion via a Cl-independent, DIDS-insensitive, carrier-mediated process as well as …