Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases

L Abenavoli, AA Izzo, N Milić, C Cicala… - Phytotherapy …, 2018 - Wiley Online Library
Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic
herb with a 2,000‐year history of use. MT fruits contain a mixture of flavonolignans …

Silymarin as a natural antioxidant: an overview of the current evidence and perspectives

PF Surai - Antioxidants, 2015 - mdpi.com
Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant containing various
flavonolignans (with silybin being the major one), has received a tremendous amount of …

Botanicals and their bioactive phytochemicals for women's health

BM Dietz, A Hajirahimkhan, TL Dunlap… - Pharmacological reviews, 2016 - ASPET
Botanical dietary supplements are increasingly popular for women's health, particularly for
older women. The specific botanicals women take vary as a function of age. Younger …

Role of silymarin in cancer treatment: facts, hypotheses, and questions

T Koltai, L Fliegel - Journal of Evidence-Based Integrative …, 2022 - journals.sagepub.com
The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence

I Marmouzi, A Bouyahya, SM Ezzat, M El Jemli… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Silybum marianum (L.) Gaertn. or Milk thistle is a
medicinal plant native to Northern Africa, Southern Europe, Southern Russia and Anatolia. It …

Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells

K Jiang, W Wang, X Jin, Z Wang, Z Ji… - Oncology …, 2015 - spandidos-publications.com
Silibinin, derived from the milk thistle plant (Silybum marianum), has anticancer and
chemopreventive properties. Silibinin has been reported to inhibit the growth of various …

Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin

V Tvrdý, J Pourová, E Jirkovský, V Křen… - Medicinal Research …, 2021 - Wiley Online Library
Silymarin is an extract from the seeds (fruits) of Silybum marianum that contains
flavonolignans and flavonoids. Although it is frequently used as a hepatoprotective agent, its …

Culinary and nutritional value of edible wild plants from northern Spain rich in phenolic compounds with potential health benefits

AG Pereira, M Fraga-Corral, P García-Oliveira… - Food & function, 2020 - pubs.rsc.org
Wild edible plants (WEPs) have been consumed since ancient times. They are considered
as non-domesticated plants that grow spontaneously in nature, particularly in forests and …

Pharmacological applications of antioxidants: lights and shadows

L Saso, O Firuzi - Current Drug Targets, 2014 - ingentaconnect.com
Oxidative stress is linked with many pathologies ranging from cancer to neurodegenerative
disorders and antioxidants have presumably therapeutic value in such diseases. In this …

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson's disease …

P Ganesan, HM Ko, IS Kim, DK Choi - International journal of …, 2015 - Taylor & Francis
Oxidative stress plays a very critical role in neurodegenerative diseases, such as
Parkinson's disease (PD), which is the second most common neurodegenerative disease …