Bioengineered livers are promising in vitro models for drug testing, toxicological studies, and
as disease models, and might in the future be an alternative for donor organs to treat end …

Over the last decade, water-soluble polyisocyanopeptides (PICs) have emerged as a new
class of biomimetic polymers. Analogous to biopolymers, PICs exhibit a semi-flexible nature; …

Adoptive T cell therapy has successfully been implemented for the treatment of cancer.
Nevertheless, ex vivo expansion of T cells by artificial antigen-presenting cells (aAPCs) …

A variety of bioactive materials developed to expand T cells for adoptive transfer into cancer
patients are currently evaluated in the clinic. In most cases, T cell activating biomolecules …

T cells require a co‐stimulatory signal in addition to T‐cell receptor (TCR) stimulation to
achieve full activation. While most studies focus on the co‐stimulatory receptor CD28, little is …

Widespread application of cytokine‐based therapies is hampered by severe toxic side
effects, resulting from off‐target (immune) cell stimulation. This emphasizes the need for …

Multivalent scaffolds that carry multiple molecules with immunophenotyping or
immunomodulatory properties are invaluable tools for studying and modulating specific …

Adoptive T cell therapy (ACT) has achieved remarkable results in the treatment of cancer.
Tumor‐antigen specific T cells are the main players in the clearance of cancerous cells, but …

Immunotherapies are a powerful strategy to treat cancer by modulating the immune system
to raise an anti-tumor immune response. A prime example of immunotherapies are cytokines …

Over the years, synthetic hydrogels have proven remarkably useful as cell culture matrixes
to elucidate the role of the extracellular matrix (ECM) on cell behavior. Yet, their lack of …