Smart bioorthogonal nanozymes: from rational design to appropriate bioapplications

W Zhang, J Zhu, J Ren, X Qu - Advanced Materials, 2024 - Wiley Online Library
Bioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological
processes in living systems. As the great advancement of nanotechnology in recent years …

Biomimetic and bioorthogonal nanozymes for biomedical applications

C Keum, CM Hirschbiegel, S Chakraborty, S Jin… - Nano …, 2023 - Springer
Nanozymes mimic the function of enzymes, which drive essential intracellular chemical
reactions that govern biological processes. They efficiently generate or degrade specific …

Flexible curcumin-loaded Zn-MOF hydrogel for long-term drug release and antibacterial activities

J Li, Y Yan, Y Chen, Q Fang, MI Hussain… - International Journal of …, 2023 - mdpi.com
Management of chronic inflammation and wounds has always been a key issue in the
pharmaceutical and healthcare sectors. Curcumin (CCM) is an active ingredient extracted …

Lewis acid-driven self-assembly of diiridium macrocyclic catalysts imparts substrate selectivity and glutathione tolerance

HD Nguyen, RD Jana, DT Campbell, TV Tran… - Chemical Science, 2023 - pubs.rsc.org
Molecular inorganic catalysts (MICs) tend to have solvent-exposed metal centers that lack
substrate specificity and are easily inhibited by biological nucleophiles. Unfortunately, these …

Designing intelligent bioorthogonal nanozymes: Recent advances of stimuli-responsive catalytic systems for biomedical applications

Y Zhang, F Lei, W Qian, C Zhang, Q Wang, C Liu… - Journal of Controlled …, 2024 - Elsevier
Bioorthogonal nanozymes have emerged as a potent tool in biomedicine due to their unique
ability to perform enzymatic reactions that do not interfere with native biochemical …

Controlled bioorthogonal activation of Bromodomain-containing protein 4 degrader by co-delivery of PROTAC and Pd-catalyst for tumor-specific therapy

Z Li, T Jiang, X Yuan, B Li, C Wu, Y Li, Y Huang… - Journal of Controlled …, 2024 - Elsevier
The precise and safe treatment of bioorthogonal prodrug system is hindered by separate
administration of prodrug and its activator, which often results in poor therapeutic effects and …

Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications

R Huang, CM Hirschbiegel, V Lehot, L Liu… - Advanced …, 2024 - Wiley Online Library
The incorporation of transition metal catalysts (TMCs) into nanoscaffolds generates
nanocatalysts that replicate key aspects of enzymatic behavior. The TMCs can access …

Designer Nanoreactors for Bioorthogonal Catalysis

A Kumar, IS Lee - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus The evolutionary complexity of compartmentalized biostructures (such as cells
and organelles) endows life-sustaining multistep chemical cascades and intricate living …

Emerging nanotechnology backed formulations for the management of atopic dermatitis

RK Mahato, M Singh, H Pathak, NR Gogoi… - Therapeutic …, 2023 - Taylor & Francis
Atopic dermatitis is a prevalent chronic skin inflammation affecting 2.1 to 4.1% of adults
globally. The complexity of its pathogenesis and the relapsing nature make it challenging to …

Modulation of Gold Nanoparticle Ligand Structure–Dynamic Relationships Probed Using Solution NMR

R Huang, S Fedeli, CM Hirschbiegel, X Zhang… - ACS Nanoscience …, 2023 - ACS Publications
Ligand dynamics plays a critical role in the chemical and biological properties of gold
nanoparticles (AuNPs). In this study, ligands featuring hydrophobic alkanethiol interiors and …