Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing
compounds in modern technology and daily life, the explosive development of the …

Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

Animal testing is used in pharmaceutical and industrial research to predict human toxicity,
and yet analysis suggests that animal models are poor predictors of drug safety in humans …

Advancement in the field of computational research has made it possible for the in silico
methods to offer significant benefits to both regulatory needs and requirements for risk …

ChEMBL is an open large-scale bioactivity database (https://www. ebi. ac. uk/chembl),
previously described in the 2012 and 2014 Nucleic Acids Research Database Issues. Since …

Chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET), play key
roles in drug discovery and development. A high-quality drug candidate should not only …

Organoids—Preclinical Models of Disease An organoid is a three-dimensional construct
composed of multiple cell types that originates from stem cells through self-organization and …

This review offers a systematic discussion about nanotoxicology and nanosafety associated
with nanomaterials during manufacture and further biomedical applications. A detailed …

With the increasing research and development (R&D) difficulty of new molecular entities
(NMEs), novel drug delivery systems (DDSs) are attracting widespread attention. This review …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …