Desmin myopathy is a recently identified disease associated with mutations in desmin or αB‐
crystallin. Typically, the illness presents with lower limb muscle weakness slowly spreading …

Myosin in adult murine skeletal muscle is composed primarily of three adult fast myosin
heavy chain (MyHC) isoforms. These isoforms, MyHC-IIa,-IId, and-IIb, are> 93% identical at …

A null mutation was introduced into the mouse desmin gene by homologous recombination.
The desmin knockout mice (Des−/−) develop normally and are fertile. However, defects were …

In this study, using a high-resolution gel electrophoresis technique, we have characterized
the myosin heavy chain composition in different skeletal muscle of the mouse during …

This study explores the importance of creatine kinase (CK) in the regulation of muscle
mitochondrial respiration in human subjects depending on their level of physical activity …

Developmental changes in force‐generating capacity and Ca2+ sensitivity of contraction in
murine hearts were correlated with changes in myosin heavy chain (MHC) and troponin (Tn) …

The accurate classification of skeletal muscle fiber types according to myosin heavy chain
(MyHC) polymorphism remains a difficult task in the pig. Combined myofibrillar ATPase and …

Duchenne muscular dystrophy is a frequent muscular disorder caused by mutations in the
gene encoding dystrophin, a cytoskeletal protein that contributes to the stabilization of …

Desminopathy is one of the most common intermediate filament human disorders
associated with mutations in closely interacting proteins, desmin and alphaB-crystallin. The …

Aims: In humans, skeletal muscle capillarization and the vascular endothelial growth factor
(VEGF) mRNA response to acute exercise are lower in aged compared with young. The …