Abstract AMD3100 (plerixafor), a CXCR4 antagonist, has opened a variety of avenues for
potential therapeutic approaches in different refractory diseases. The CXCL12/CXCR4 axis …

The heat shock protein (Hsps) superfamily, also known as molecular chaperones, are highly
conserved and present in all living organisms and play vital roles in protein fate. The …

Background Multiple iterations of chimeric antigen receptors (CARs) have been developed,
mainly focusing on intracellular signaling modules. However, the effect of non-signaling …

Despite advances in combinatorial chemotherapy regimens and the advent of
intraperitoneal chemotherapy administration, current therapeutic options for ovarian cancer …

Malignant mesothelioma is an aggressive cancer whose pathogenesis is causally linked to
occupational exposure to asbestos. Familial clusters of mesotheliomas have been observed …

Epithelial ovarian cancer (EOC) is one important cause of gynecologic cancer-related death.
Currently, the mainstay of ovarian cancer treatment consists of cytoreductive surgery and …

Breast cancer was ranked first in global cancer incidence in 2020, and HER2
overexpression in breast cancer accounts for 20–30% of breast cancer patients. Current …

Abstract AMD3100 (plerixafor), a CXCR4 antagonist, has been demonstrated to suppress
tumor growth and modulate intratumoral T-cell trafficking. However, the effect of AMD3100 …

Abstract Heat shock protein 70 (HSP70) is a highly conserved protein functioning as a
“molecular chaperone”, which is integral to protein folding and maturation. In addition to its …

Simple Summary Mesothelioma is a deadly disease with a dismal prognosis. Since its
discovery, mesothelin, a cell surface protein, has been a promising biomarker and …