From genes to drugs: CYP2C19 and pharmacogenetics in clinical practice
Q Shubbar, A Alchakee, KW Issa, AJ Adi… - Frontiers in …, 2024 - frontiersin.org
The CYP2C19 gene is frequently included in different pharmacogenomic panels tested in
clinical practice, due to its involvement in the metabolism of a myriad of frequently …
clinical practice, due to its involvement in the metabolism of a myriad of frequently …
Pharmacokinetic correlates of clinical response in a naturalistic sample of escitalopram-treated patients
Objective We assessed pharmacokinetic correlates of treatment response to escitalopram
using a large therapeutic drug monitoring database. Methods A large naturalistic sample of …
using a large therapeutic drug monitoring database. Methods A large naturalistic sample of …
A new intervention for implementation of pharmacogenetics in psychiatry: A description of the PSY-PGx clinical study
(1) Background Pharmacological treatment for psychiatric disorders has shown to only be
effective in about one-third of patients, as it is associated with frequent treatment failure …
effective in about one-third of patients, as it is associated with frequent treatment failure …
The duration of lithium use and biological ageing: telomere length, frailty, metabolomic age and all-cause mortality
Lithium is an established first-line treatment for bipolar disorder. Beyond its therapeutic effect
as a mood stabiliser, lithium exhibits potential anti-ageing effects. This study aimed to …
as a mood stabiliser, lithium exhibits potential anti-ageing effects. This study aimed to …
A comprehensive Thai pharmacogenomics database (TPGxD‐1): Phenotype prediction and variants identification in 942 whole‐genome sequencing data
S John, S Klumsathian, P Own‐eium… - Clinical and …, 2024 - Wiley Online Library
Computational methods analyze genomic data to identify genetic variants linked to drug
responses, thereby guiding personalized medicine. This study analyzed 942 whole‐genome …
responses, thereby guiding personalized medicine. This study analyzed 942 whole‐genome …